Reaction profile

The FDA adverse-event record for salivary staining

46 FDA adverse-event reports reference salivary staining (VeDDRA 2542). See the species, breeds, and drugs most associated with it below.

46
reports citing this reaction
6.5%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
46
Total Reports
3
Deaths
6.5%
Death Rate

Species Most Affected

Dog 43
Cat 3

Breeds Most Affected

Crossbred Canine/dog 3
Retriever - Golden 3
Mountain Dog - Bernese 3
Shepherd Dog - Australian 3
Retriever - Labrador 2
Siberian Husky 2
Shih Tzu 2
Terrier - West Highland White 2
Dog (unknown) 2
Terrier (unspecified) 2

Associated Drugs

Carprofen 11
Maropitant Citrate 7
Oclacitinib Maleate 7
Gabapentin 7
Pyrantel Pamoate;Sarolaner 6
Bedinvetmab 4
Enrofloxacin 4
Cephalexin 4
Fentanyl 4
Pantoprazole 4
Diphenhydramine 3
Fluralaner Chew Tablets 3
Ketoconazole 3
Famotidine 3
Methadone 3
Omeprazole 3
Ampicillin 3
Rabies Vaccine 3
Spinosad 2
Fipronil 2

Salivary staining Reaction Insights

46 reports name Salivary staining; 3 recorded a death outcome (6.5% of reported events, not a population-level mortality rate). VeDDRA code: 2542.

By species: Dog (43 reports), Cat (3 reports). By breed: Crossbred Canine/dog (3), Retriever - Golden (3), Mountain Dog - Bernese (3).

Most co-reported drugs: Carprofen (11 reports), Maropitant Citrate (7 reports), Oclacitinib Maleate (7 reports), Gabapentin (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.