Reaction profile

The FDA adverse-event record for ineffective, production (milk)

204 FDA adverse-event reports reference ineffective, production (milk) (VeDDRA 99140). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1024 of 2,481
by report volume (all reactions)
204
reports citing this reaction
1.5%
death-coded share
Cattle
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. INEFFECTIVE, PRODUCTION (MILK) has 204 reports now versus 204 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to INEFFECTIVE, PRODUCTION (MILK) changes

FDA AER · VeDDRA plate

Code 99140 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-CATTLE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 204 reports
  • DEATH-LOW 1.5%
  • MID-PACK #1024/2481
  • PHOTO-FINISH Stress leukogram
  • SPECIES-CATTLE Cattle · 204
  • DRUG-LEAD Sometribove · 168
  • DESK-WIDE 9 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Stress leukogram (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around INEFFECTIVE, PRODUCTION

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Heart valve disorder · near205INEFFECTIVE, PRODUCTI… · thi…204Stress leukogram · near204Anal irritation · near203Glaucoma · near203Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around INEFFECTIVE, PRODUCTION (MILK)

INEFFECTIVE, PRODUCTION (MILK): low death-coded share in the FDA AER plate

Signature read: INEFFECTIVE, PRODUCTION (MILK)'s 1.5% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 3 of 204 reports (1.5% of named reports). Nearest volume peer: Stress leukogram (±0 reports). Lead species Cattle (204). Lead co-reported drug Sometribove (168).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Sometribove appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cattle 204

Breeds Most Affected

Holstein-Friesian also known as Holstein 122
Cattle (unknown) 34
Mixed (Cattle) 20
Jersey 12
Crossbred Bovine/Cattle 10
Cattle (other) 3
Holstein-Friesian - Swedish 1
Holstein-Friesian - French Black Pied 1
Guernsey 1

Associated Drugs

Sometribove 168
Monensin Sodium 87
Sometribove Zinc Suspension 12
Monensin 1
Oxytocin 1
Zinc + Methionine 1
Probiotic (Unknown) 1
Energy Booster Feed Additive (Unknown) 1

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for INEFFECTIVE, PRODUCTION (MILK), both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (204 here).

Similar death-coded share

Nearest other reactions by death-coded share (1.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for INEFFECTIVE, PRODUCTION (MILK) (#1024 of 2,481 by report volume); death-coded 1.5%. PlainBreed reaction plate · death-coded share stamp 1.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →