Reaction profile

The FDA adverse-event record for ineffective, production (milk)

204 FDA adverse-event reports reference ineffective, production (milk) (VeDDRA 99140). See the species, breeds, and drugs most associated with it below.

204
reports citing this reaction
1.5%
death-coded share
Cattle
most-affected species
Sometribove
most-associated drug
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204
Total Reports
3
Deaths
1.5%
Death Rate

Species Most Affected

Cattle 204

Breeds Most Affected

Holstein-Friesian also known as Holstein 122
Cattle (unknown) 34
Mixed (Cattle) 20
Jersey 12
Crossbred Bovine/Cattle 10
Cattle (other) 3
Holstein-Friesian - Swedish 1
Holstein-Friesian - French Black Pied 1
Guernsey 1

Associated Drugs

Sometribove 168
Monensin Sodium 87
Sometribove Zinc Suspension 12
Monensin 1
Oxytocin 1
Zinc + Methionine 1
Probiotic (Unknown) 1
Energy Booster Feed Additive (Unknown) 1

INEFFECTIVE, PRODUCTION (MILK) Reaction Insights

204 reports name INEFFECTIVE, PRODUCTION (MILK); 3 recorded a death outcome (1.5% of reported events, not a population-level mortality rate). VeDDRA code: 99140.

By species: Cattle (204 reports). By breed: Holstein-Friesian also known as Holstein (122), Cattle (unknown) (34), Mixed (Cattle) (20).

Most co-reported drugs: Sometribove (168 reports), Monensin Sodium (87 reports), Sometribove Zinc Suspension (12 reports), Monensin (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.