Reaction profile

The FDA adverse-event record for slow reflexes

77 FDA adverse-event reports reference slow reflexes (VeDDRA 674). See the species, breeds, and drugs most associated with it below.

77
reports citing this reaction
15.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
77
Total Reports
12
Deaths
15.6%
Death Rate

Species Most Affected

Dog 58
Cat 14
Horse 3
Pig 1
Human 1

Breeds Most Affected

Domestic Shorthair 11
Retriever - Labrador 7
Terrier - Yorkshire 4
Chihuahua 4
Pit Bull 3
Crossbred Canine/dog 3
Horse (unknown) 2
Retriever - Golden 2
Shepherd Dog - German 2
Boxer (German Boxer) 2

Associated Drugs

Milbemycin Oxime + Spinosad 11
Maropitant Citrate 9
Bedinvetmab 8
Spinosad 6
Pyrantel Pamoate;Sarolaner 5
Robenacoxib 4
Gabapentin 4
Moxidectin 3
Glucosamine + Chondroitin 3
Selamectin 3
Carprofen 3
Cefovecin 3
Oclacitinib Maleate 3
Afoxolaner 3
Buprenorphine 3
Miconazole Nitrate + Polymyxin B Sulfate + Prednisolone Acetate 2
Prednisone 2
Midazolam 2
Isoflurane 2
Fluralaner Chew Tablets 2

Slow reflexes Reaction Insights

77 reports name Slow reflexes; 12 recorded a death outcome (15.6% of reported events, not a population-level mortality rate). VeDDRA code: 674.

By species: Dog (58 reports), Cat (14 reports), Horse (3 reports). By breed: Domestic Shorthair (11), Retriever - Labrador (7), Terrier - Yorkshire (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (11 reports), Maropitant Citrate (9 reports), Bedinvetmab (8 reports), Spinosad (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.