Reaction profile

The FDA adverse-event record for haemolysis nos

131 FDA adverse-event reports reference haemolysis nos (VeDDRA 2156). See the species, breeds, and drugs most associated with it below.

131
reports citing this reaction
14.5%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
131
Total Reports
19
Deaths
14.5%
Death Rate

Species Most Affected

Dog 113
Cat 16
Horse 2

Breeds Most Affected

Chihuahua 11
Domestic Shorthair 10
Retriever - Labrador 10
Maltese 8
Crossbred Canine/dog 7
Terrier - Yorkshire 6
Terrier (unspecified) 5
Shepherd Dog - German 5
Pinscher - Miniature 3
Spaniel (unspecified) 3

Associated Drugs

Trilostane 109
Desoxycortone Pivalate 11
Gabapentin 11
Bexagliflozin 11
Prednisone 10
Carprofen 10
Metronidazole 7
Benazepril 6
Grapiprant 6
Fluoxetine 5
Water, Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride 5
Doxycycline 5
Leptospirosis Vaccine 5
Maropitant Citrate 5
Ursodiol 4
Pimobendan 4
Oclacitinib Maleate 4
Ivermectin/Pyrantel 4
Afoxolaner 4
Bordetella Oral Vaccine 4

Haemolysis NOS Reaction Insights

131 reports name Haemolysis NOS; 19 recorded a death outcome (14.5% of reported events, not a population-level mortality rate). VeDDRA code: 2156.

By species: Dog (113 reports), Cat (16 reports), Horse (2 reports). By breed: Chihuahua (11), Domestic Shorthair (10), Retriever - Labrador (10).

Most co-reported drugs: Trilostane (109 reports), Desoxycortone Pivalate (11 reports), Gabapentin (11 reports), Bexagliflozin (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.