Reaction profile

The FDA adverse-event record for elevated amylase

2,124 FDA reports name elevated amylase, a high-volume reaction in the CVM extract (VeDDRA 2232). Plate stamps and neighbourhood peers follow.

#218 of 2,481
by report volume (all reactions)
2,124
reports citing this reaction
29.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Elevated amylase has 2,124 reports now versus 2,090 in that prior snapshot: 34 more (1.6%).

Report change
+34
Death-coded reports
+5
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Elevated amylase changes

FDA AER · VeDDRA plate

Code 2232 VOL-MID

VOL-MID · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,124 reports
  • DEATH-HOT 29.4%
  • TOP-DECILE #218/2481
  • PHOTO-FINISH Retching
  • SPECIES-DOG Dog · 1,687
  • DRUG-LEAD Maropitant Citrate · 227
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Retching (±3 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Elevated amylase

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Elevated amylase · this reac…2124Retching · near2121Application site redd… · near2120Hind limb paresis · near2118General illness · near2106Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Elevated amylase

Elevated amylase: high death-coded share in the FDA AER plate

Signature read: 625 death-coded reports is a heavy tail count for Elevated amylase in the CVM extract. Report volume is upper-third scale: 2,124 named reports in the openFDA extract. Death-coded share is upper-third: 625 of 2,124 reports (29.4% of named reports). Nearest volume peer: Retching (±3 reports). Lead species Dog (1,687). Lead co-reported drug Maropitant Citrate (227).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,687
Cat 433
Horse 2
Cattle 1
Rabbit 1

Breeds Most Affected

Domestic Shorthair 250
Retriever - Labrador 202
Crossbred Canine/dog 142
Terrier - Yorkshire 92
Boxer (German Boxer) 90
Retriever - Golden 69
Chihuahua 60
Domestic (unspecified) 47
Beagle 44
Shih Tzu 43

Associated Drugs

Maropitant Citrate 227
Carprofen 211
Trilostane 176
Oclacitinib Maleate 139
Milbemycin Oxime + Spinosad 134
Afoxolaner 111
Meloxicam 108
Fluralaner Chew Tablets 104
Cefovecin 94
Gabapentin 90
Bedinvetmab 85
Moxidectin 77
Spinosad 75
Prednisone 73
Firocoxib 65
Deracoxib 62
Enrofloxacin 61
Metronidazole 58
Ivermectin + Pyrantel As Pamoate Salt 52
Famotidine 50

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Elevated amylase, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (2,124 here).

Similar death-coded share

Nearest other reactions by death-coded share (29.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Elevated amylase (#218 of 2,481 by report volume); death-coded 29.4%. PlainBreed reaction plate · death-coded report count stamp 625 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →