Reaction profile

The FDA adverse-event record for elevated amylase

2,046 FDA adverse-event reports reference elevated amylase (VeDDRA 2232). See the species, breeds, and drugs most associated with it below.

2,046
reports citing this reaction
29.6%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
2,046
Total Reports
606
Deaths
29.6%
Death Rate

Species Most Affected

Dog 1,639
Cat 403
Horse 2
Cattle 1
Rabbit 1

Breeds Most Affected

Domestic Shorthair 228
Retriever - Labrador 196
Crossbred Canine/dog 137
Terrier - Yorkshire 92
Boxer (German Boxer) 87
Retriever - Golden 66
Chihuahua 59
Domestic (unspecified) 47
Beagle 44
Shih Tzu 42

Associated Drugs

Maropitant Citrate 216
Carprofen 207
Trilostane 169
Milbemycin Oxime + Spinosad 133
Oclacitinib Maleate 133
Afoxolaner 108
Meloxicam 106
Fluralaner Chew Tablets 104
Cefovecin 87
Gabapentin 80
Moxidectin 76
Bedinvetmab 76
Spinosad 75
Prednisone 71
Firocoxib 65
Deracoxib 61
Enrofloxacin 59
Metronidazole 54
Ivermectin + Pyrantel As Pamoate Salt 52
Famotidine 49

Elevated amylase Reaction Insights

2,046 reports name Elevated amylase; 606 recorded a death outcome (29.6% of reported events, not a population-level mortality rate). VeDDRA code: 2232.

By species: Dog (1,639 reports), Cat (403 reports), Horse (2 reports). By breed: Domestic Shorthair (228), Retriever - Labrador (196), Crossbred Canine/dog (137).

Most co-reported drugs: Maropitant Citrate (216 reports), Carprofen (207 reports), Trilostane (169 reports), Milbemycin Oxime + Spinosad (133 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.