Reaction profile

The FDA adverse-event record for ear twitching

213 FDA adverse-event reports reference ear twitching (VeDDRA 1138). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#995 of 2,481
by report volume (all reactions)
213
reports citing this reaction
8.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Ear twitching has 213 reports now versus 210 in that prior snapshot: 3 more (1.4%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Ear twitching changes

FDA AER · VeDDRA plate

Code 1138 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 213 reports
  • DEATH-PAR 8.5%
  • MID-PACK #995/2481
  • PHOTO-FINISH Drug dose prescribing…
  • SPECIES-DOG Dog · 112
  • DRUG-LEAD Milbemycin Oxime… · 26
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Drug dose prescribing error (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Ear twitching

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Drug dose prescribing… · near213Ear twitching · this reaction213Ileus · near213Injection site prurit… · near213Aspiration pneumonia · near212Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Ear twitching

What the FDA AER plate says about Ear twitching

Signature read: death-coded share at 8.5% is the most distinctive outcome stamp on Ear twitching. Report volume sits in the middle third of the reaction corpus. 18 of 213 reports were death-coded (8.5% of named reports, not a population mortality rate). Nearest volume peer: Drug dose prescribing error (±0 reports). Lead species Dog (112). Lead co-reported drug Milbemycin Oxime + Spinosad (26).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 112
Cat 99
Rabbit 1
Cattle 1

Breeds Most Affected

Domestic Shorthair 64
Crossbred Canine/dog 11
Retriever - Golden 9
Chihuahua 7
Cat (unknown) 7
Retriever - Labrador 7
Domestic (unspecified) 6
Domestic Longhair 6
Shepherd Dog - Australian 6
Bichon Frise 4

Associated Drugs

Milbemycin Oxime + Spinosad 26
Afoxolaner 17
Spinosad 15
Imidacloprid + Moxidectin 15
Fluralaner Spot-On Solution 15
Selamectin 14
Sarolaner 8
Fluralaner 13.64% 12-Week Chew 8
Emodepside + Praziquantel 7
Vitamins 6
Selamectin;Sarolaner 6
Pyrantel Pamoate;Sarolaner 6
Buprenorphine 6
Eprinomectin + Esafoxolaner + Praziquantel 6
Moxidectin 5
Maropitant Citrate 5
Ivermectin + Pyrantel As Pamoate Salt 5
Butorphanol 4
Phenobarbital 4
Cefovecin 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Ear twitching, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (213 here).

Similar death-coded share

Nearest other reactions by death-coded share (8.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Ear twitching (#995 of 2,481 by report volume); death-coded 8.5%. PlainBreed reaction plate · death-coded share stamp 8.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →