Reaction profile

The FDA adverse-event record for respiratory tract disorder nos

918 FDA adverse-event reports reference respiratory tract disorder nos (VeDDRA 1180). See the species, breeds, and drugs most associated with it below.

918
reports citing this reaction
48.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
918
Total Reports
446
Deaths
48.6%
Death Rate

Species Most Affected

Dog 482
Cattle 199
Cat 170
Pig 27
Human 13
Horse 13
Chicken 3
Goat 2
Fish 1
Sheep 1

Breeds Most Affected

Domestic Shorthair 83
Cattle (unknown) 54
Crossbred Bovine/Cattle 53
Retriever - Labrador 40
Crossbred Canine/dog 33
Chihuahua 33
Mixed (Cattle) 26
Domestic (unspecified) 25
Cattle (other) 21
Unknown 20

Associated Drugs

Milbemycin Oxime + Spinosad 69
Monensin Sodium 66
Maropitant Citrate 52
Enrofloxacin 46
Cefovecin 46
Moxidectin 44
Fenbendazole 42
Tylosin Phosphate 37
Oclacitinib Maleate 37
Spinosad 36
Dexmedetomidine Hydrochloride 32
Ractopamine Hydrochloride 29
Carprofen 27
Prednisone 27
Selamectin 25
Dexamethasone 25
Trenbolone; Estradiol; Tylosin Tartrate 25
Doxycycline 23
Isoflurane 23
Meloxicam 22

Respiratory tract disorder NOS Reaction Insights

918 reports name Respiratory tract disorder NOS; 446 recorded a death outcome (48.6% of reported events, not a population-level mortality rate). VeDDRA code: 1180.

By species: Dog (482 reports), Cattle (199 reports), Cat (170 reports). By breed: Domestic Shorthair (83), Cattle (unknown) (54), Crossbred Bovine/Cattle (53).

Most co-reported drugs: Milbemycin Oxime + Spinosad (69 reports), Monensin Sodium (66 reports), Maropitant Citrate (52 reports), Enrofloxacin (46 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.