Reaction profile

The FDA adverse-event record for prolapse of the nictitating membrane

178 FDA adverse-event reports reference prolapse of the nictitating membrane (VeDDRA 1103). See the species, breeds, and drugs most associated with it below.

178
reports citing this reaction
11.8%
death-coded share
Cat
most-affected species
Spinosad
most-associated drug
Verify with FDA CVM →
178
Total Reports
21
Deaths
11.8%
Death Rate

Species Most Affected

Cat 91
Dog 86
Cattle 1

Breeds Most Affected

Domestic (unspecified) 40
Domestic Shorthair 27
Retriever - Labrador 12
Boxer (German Boxer) 11
Crossbred Canine/dog 9
Retriever - Golden 7
Cat (unknown) 5
Maine Coon 4
Domestic Longhair 4
Spaniel - Cocker American 3

Associated Drugs

Spinosad 21
Selamectin 13
Milbemycin Oxime + Spinosad 13
Cefovecin Sodium 10
Meloxicam 7
Carprofen 7
Cefovecin 7
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 7
Isoflurane 6
Pyrantel Pamoate;Sarolaner 6
Oclacitinib Maleate 6
Ketamine Hydrochloride 5
Dexmedetomidine Hydrochloride 5
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 5
Imidacloprid, Moxidectin 4
Maropitant 4
Nitenpyram 4
Emodepside + Praziquantel 4
Maropitant Citrate 4
Trilostane 4

Prolapse of the nictitating membrane Reaction Insights

178 reports name Prolapse of the nictitating membrane; 21 recorded a death outcome (11.8% of reported events, not a population-level mortality rate). VeDDRA code: 1103.

By species: Cat (91 reports), Dog (86 reports), Cattle (1 reports). By breed: Domestic (unspecified) (40), Domestic Shorthair (27), Retriever - Labrador (12).

Most co-reported drugs: Spinosad (21 reports), Selamectin (13 reports), Milbemycin Oxime + Spinosad (13 reports), Cefovecin Sodium (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.