Reaction profile

The FDA adverse-event record for pr-lung(s), edema

207 FDA adverse-event reports reference pr-lung(s), edema (VeDDRA 99630). See the species, breeds, and drugs most associated with it below.

207
reports citing this reaction
100.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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207
Total Reports
207
Deaths
100.0%
Death Rate

Species Most Affected

Dog 114
Cat 64
Cattle 25
Sheep 2
Horse 1
Ferret 1

Breeds Most Affected

Domestic Shorthair 27
Domestic (unspecified) 25
Crossbred Canine/dog 12
Retriever - Labrador 12
Shepherd Dog - German 9
Dachshund (unspecified) 6
Holstein-Friesian also known as Holstein 6
Crossbred Bovine/Cattle 6
Spaniel - King Charles Cavalier 5
Chihuahua 5

Associated Drugs

Milbemycin Oxime + Spinosad 45
Spinosad 24
Cefovecin 14
Cefovecin Sodium 13
Moxidectin 13
Maropitant Citrate 10
Dexmedetomidine Hydrochloride 9
Pyrantel Pamoate 6
Imidacloprid + Moxidectin 6
Fluralaner Chew Tablets 6
Tiletamine, Zolazepam 5
Carprofen 5
Rabies Vaccine 5
Dexamethasone 5
Meloxicam 5
Maropitant 4
Monensin 4
Enrofloxacin 4
Robenacoxib 4
Famotidine 4

PR-LUNG(S), EDEMA Reaction Insights

207 reports name PR-LUNG(S), EDEMA; 207 recorded a death outcome (100.0% of reported events, not a population-level mortality rate). VeDDRA code: 99630.

By species: Dog (114 reports), Cat (64 reports), Cattle (25 reports). By breed: Domestic Shorthair (27), Domestic (unspecified) (25), Crossbred Canine/dog (12).

Most co-reported drugs: Milbemycin Oxime + Spinosad (45 reports), Spinosad (24 reports), Cefovecin (14 reports), Cefovecin Sodium (13 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.