Reaction profile

The FDA adverse-event record for localised oedema (not application site)

501 FDA adverse-event reports reference localised oedema (not application site) (VeDDRA 1586). See the species, breeds, and drugs most associated with it below.

501
reports citing this reaction
20.2%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
501
Total Reports
101
Deaths
20.2%
Death Rate

Species Most Affected

Dog 367
Horse 50
Cat 39
Human 18
Cattle 16
Sheep 4
Pig 1
Ferret 1
Pheasant 1
Other Birds 1

Breeds Most Affected

Retriever - Labrador 50
Domestic Shorthair 26
Boxer (German Boxer) 22
Retriever - Golden 22
Unknown 21
Chihuahua 17
Terrier - Bull - American Pit 14
Quarter Horse 13
Shepherd Dog - German 13
Terrier - Boston 12

Associated Drugs

Carprofen 77
Maropitant Citrate 46
Moxidectin 44
Oclacitinib Maleate 41
Famotidine 33
Gabapentin 32
Diphenhydramine 31
Prednisone 31
Cefovecin 26
Tramadol 24
Milbemycin Oxime + Spinosad 22
Diphenhydramine Hcl 21
Polysulfated Glycosaminoglycan 19
Meloxicam 19
Tigilanol Tiglate 19
Dexamethasone 18
Selamectin 17
Metronidazole 17
Enrofloxacin 15
Deracoxib 15

Localised oedema (not application site) Reaction Insights

501 reports name Localised oedema (not application site); 101 recorded a death outcome (20.2% of reported events, not a population-level mortality rate). VeDDRA code: 1586.

By species: Dog (367 reports), Horse (50 reports), Cat (39 reports). By breed: Retriever - Labrador (50), Domestic Shorthair (26), Boxer (German Boxer) (22).

Most co-reported drugs: Carprofen (77 reports), Maropitant Citrate (46 reports), Moxidectin (44 reports), Oclacitinib Maleate (41 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.