Plantigrade posture

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VeDDRA Code: 2632

96 adverse event reports referencing this reaction

96
Total Reports
13
Deaths
1350.0%
Death Rate

Species Most Affected

Cat 75
Dog 21

Breeds Most Affected

Domestic Shorthair 49
Domestic Longhair 5
Cat (other) 5
Retriever - Labrador 4
Maine Coon 3
Siamese 3
Birman (Sacred Birman) 2
Retriever - Golden 2
Cat (unknown) 2
Domestic Mediumhair 2

Associated Drugs

Frunevetmab 37
Bedinvetmab 15
Gabapentin 14
Velagliflozin Proline Monohydrate 9
Buprenorphine 8
Robenacoxib 7
Prednisolone 6
Bexagliflozin 6
Carprofen 6
Galliprant 5
Oclacitinib Maleate 5
Maropitant Citrate 4
Methimazole 4
Mirtazapine 4
Isoflurane 4
Insulin Injectable Vial 3
Enrofloxacin 3
Cefovecin 3
Protamine Zinc Recombinant Human Insulin 3
Trazodone 3

Data Summary

Metric Value
Total reports referencing reaction 96
Reports with fatal outcome 13
Case-fatality rate (reported events) 1350.0%
Species observed 2
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2632.

Plantigrade posture Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 96 adverse event reports that reference Plantigrade posture as a reaction term, including 13 reports with a death outcome — a 1350.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2632, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Plantigrade posture appears most frequently in reports for Cat (75 reports), Dog (21 reports) — with Cat dominating at 75 entries. Within those species, the breeds most often named alongside this reaction are Domestic Shorthair (49), Domestic Longhair (5), Cat (other) (5). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Plantigrade posture are Frunevetmab (37 reports), Bedinvetmab (15 reports), Gabapentin (14 reports), Velagliflozin Proline Monohydrate (9 reports), with Frunevetmab appearing alongside this reaction in 37 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial