Reaction profile

The FDA adverse-event record for involuntary movement

161 FDA adverse-event reports reference involuntary movement (VeDDRA 1558). See the species, breeds, and drugs most associated with it below.

161
reports citing this reaction
9.9%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
161
Total Reports
16
Deaths
9.9%
Death Rate

Species Most Affected

Dog 142
Cat 16
Horse 2
Cattle 1

Breeds Most Affected

Retriever - Labrador 17
Domestic Shorthair 13
Retriever - Golden 12
Crossbred Canine/dog 9
Maltese 7
Shih Tzu 6
Terrier - Jack Russell 5
Chihuahua 5
Terrier - Yorkshire 5
Boxer (German Boxer) 5

Associated Drugs

Afoxolaner 32
Fluralaner Chew Tablets 17
Sarolaner 17
Pyrantel Pamoate;Sarolaner 14
Ivermectin + Pyrantel As Pamoate Salt 13
Milbemycin Oxime + Spinosad 8
Bedinvetmab 8
Fluralaner 13.64% 12-Week Chew 7
Spinosad 6
Oclacitinib Maleate 6
Gabapentin 5
Fluoxetine 4
Anti-Il31 Mab Mcs Lot #1283563 4
Ivermectin 3
Isoflurane 3
Selamectin;Sarolaner 3
Fluralaner Spot-On Solution 3
Prednisone 3
Amantidine 3
Enalapril 3

Involuntary movement Reaction Insights

161 reports name Involuntary movement; 16 recorded a death outcome (9.9% of reported events, not a population-level mortality rate). VeDDRA code: 1558.

By species: Dog (142 reports), Cat (16 reports), Horse (2 reports). By breed: Retriever - Labrador (17), Domestic Shorthair (13), Retriever - Golden (12).

Most co-reported drugs: Afoxolaner (32 reports), Fluralaner Chew Tablets (17 reports), Sarolaner (17 reports), Pyrantel Pamoate;Sarolaner (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.