Reaction profile

The FDA adverse-event record for musculoskeletal disorder nos

3,119 FDA adverse-event reports reference musculoskeletal disorder nos (VeDDRA 1120). See the species, breeds, and drugs most associated with it below.

3,119
reports citing this reaction
21.0%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
3,119
Total Reports
655
Deaths
21.0%
Death Rate

Species Most Affected

Dog 2,653
Cat 343
Cattle 42
Horse 37
Chicken 13
Human 12
Pig 7
Turkey 5
Rabbit 4
Other Birds 1

Breeds Most Affected

Retriever - Labrador 319
Domestic Shorthair 193
Crossbred Canine/dog 149
Dog (unknown) 135
Shepherd Dog - German 128
Retriever - Golden 126
Chihuahua 124
Terrier - Yorkshire 78
Shih Tzu 77
Boxer (German Boxer) 68

Associated Drugs

Bedinvetmab 559
Milbemycin Oxime + Spinosad 405
Carprofen 370
Afoxolaner 217
Gabapentin 208
Oclacitinib Maleate 161
Maropitant Citrate 137
Ivermectin + Pyrantel As Pamoate Salt 137
Cefovecin 119
Prednisone 114
Sarolaner 102
Spinosad 98
Frunevetmab 98
Moxidectin 97
Pyrantel Pamoate;Sarolaner 95
Selamectin 93
Fluralaner Chew Tablets 87
Tramadol 86
Milbemycin Oxime + Praziquantel 82
Grapiprant 70

Musculoskeletal disorder NOS Reaction Insights

3,119 reports name Musculoskeletal disorder NOS; 655 recorded a death outcome (21.0% of reported events, not a population-level mortality rate). VeDDRA code: 1120.

By species: Dog (2,653 reports), Cat (343 reports), Cattle (42 reports). By breed: Retriever - Labrador (319), Domestic Shorthair (193), Crossbred Canine/dog (149).

Most co-reported drugs: Bedinvetmab (559 reports), Milbemycin Oxime + Spinosad (405 reports), Carprofen (370 reports), Afoxolaner (217 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.