Reaction profile

The FDA adverse-event record for hard stool

96 FDA adverse-event reports reference hard stool (VeDDRA 2677). See the species, breeds, and drugs most associated with it below.

96
reports citing this reaction
18.8%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
96
Total Reports
18
Deaths
18.8%
Death Rate

Species Most Affected

Dog 54
Cat 31
Horse 7
Cattle 3
Chicken 1

Breeds Most Affected

Domestic Shorthair 19
Retriever - Labrador 6
Retriever - Golden 4
Dog (unknown) 4
Shih Tzu 3
Terrier (unspecified) 3
Chihuahua 3
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2
Maltese 2
Pug 2

Associated Drugs

Trilostane 12
Maropitant Citrate 7
Milbemycin Oxime + Praziquantel 7
Afoxolaner 6
Lotilaner 5
Divested Suanovil 50 4
Metronidazole 4
Ivermectin + Pyrantel As Pamoate Salt 4
Oclacitinib Maleate 4
Gabapentin 4
Buprenorphine 4
Frunevetmab 4
Bedinvetmab 4
Cefovecin 3
Lactulose 3
Vitamin B12 3
Sarolaner 3
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 3
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 3
Famotidine 3

Hard stool Reaction Insights

96 reports name Hard stool; 18 recorded a death outcome (18.8% of reported events, not a population-level mortality rate). VeDDRA code: 2677.

By species: Dog (54 reports), Cat (31 reports), Horse (7 reports). By breed: Domestic Shorthair (19), Retriever - Labrador (6), Retriever - Golden (4).

Most co-reported drugs: Trilostane (12 reports), Maropitant Citrate (7 reports), Milbemycin Oxime + Praziquantel (7 reports), Afoxolaner (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.