Reaction profile

The FDA adverse-event record for hard stool

114 FDA adverse-event reports reference hard stool (VeDDRA 2677). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1331 of 2,481
by report volume (all reactions)
114
reports citing this reaction
21.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hard stool has 114 reports now versus 105 in that prior snapshot: 9 more (8.6%).

Report change
+9
Death-coded reports
+4
Death-coded share
+2.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hard stool changes

FDA AER · VeDDRA plate

Code 2677 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 114 reports
  • DEATH-HOT 21.1%
  • MID-PACK #1331/2481
  • PHOTO-FINISH Abdominal cramp
  • SPECIES-DOG Dog · 59
  • DRUG-LEAD Trilostane · 12
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abdominal cramp (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Hard stool

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Abdominal cramp · near114Application site oede… · near114Greasy skin · near114Hard stool · this reaction114Luxation/subluxation · near114Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hard stool

What the FDA AER plate says about Hard stool

Signature read: death-coded share at 21.1% is the most distinctive outcome stamp on Hard stool. Report volume sits in the middle third of the reaction corpus. 24 of 114 reports were death-coded (21.1% of named reports, not a population mortality rate). Nearest volume peer: Abdominal cramp (±0 reports). Lead species Dog (59). Lead co-reported drug Trilostane (12).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Trilostane appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 59
Cat 43
Horse 7
Cattle 4
Chicken 1

Breeds Most Affected

Domestic Shorthair 27
Retriever - Labrador 7
Retriever - Golden 4
Dog (unknown) 4
Terrier (unspecified) 3
Shih Tzu 3
Chihuahua 3
Domestic Longhair 3
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2
Poodle (unspecified) 2

Associated Drugs

Trilostane 12
Maropitant Citrate 10
Gabapentin 9
Milbemycin Oxime + Praziquantel 7
Buprenorphine 7
Afoxolaner 6
Cefovecin 6
Lotilaner 5
Cefovecin Sodium 5
Divested Suanovil 50 4
Metronidazole 4
Ivermectin + Pyrantel As Pamoate Salt 4
Oclacitinib Maleate 4
Emodepside + Praziquantel 4
Robenacoxib 4
Velagliflozin Proline Monohydrate 4
Frunevetmab 4
Bedinvetmab 4
Isoflurane 4
Fluid Therapy 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hard stool, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (114 here).

Similar death-coded share

Nearest other reactions by death-coded share (21.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hard stool (#1331 of 2,481 by report volume); death-coded 21.1%. PlainBreed reaction plate · death-coded share stamp 21.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →