Reaction profile

The FDA adverse-event record for muscle contracture

69 FDA adverse-event reports reference muscle contracture (VeDDRA 2468). See the species, breeds, and drugs most associated with it below.

69
reports citing this reaction
17.4%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
69
Total Reports
12
Deaths
17.4%
Death Rate

Species Most Affected

Dog 49
Cat 11
Horse 5
Human 3
Chicken 1

Breeds Most Affected

Domestic Shorthair 7
Crossbred Canine/dog 6
Chihuahua 5
Retriever - Labrador 3
Unknown 3
Greyhound 3
Spaniel - Cocker American 2
Shih Tzu 2
Boxer (German Boxer) 2
Dog (unknown) 2

Associated Drugs

Bedinvetmab 8
Afoxolaner 7
Butorphanol 5
Maropitant Citrate 5
Cefovecin 5
Fluralaner 13.64% 12-Week Chew 4
Tigilanol Tiglate 4
Gabapentin 4
Propofol 3
Sarolaner 3
Clodronate Disodium 3
Alfaxalone 3
Midazolam 3
Hydromorphone 3
Grapiprant 3
Lufenuron + Milbemycin Oxime 2
Lotilaner 2
Trilostane 2
Dexmedetomidine 2
Tramadol 2

Muscle contracture Reaction Insights

69 reports name Muscle contracture; 12 recorded a death outcome (17.4% of reported events, not a population-level mortality rate). VeDDRA code: 2468.

By species: Dog (49 reports), Cat (11 reports), Horse (5 reports). By breed: Domestic Shorthair (7), Crossbred Canine/dog (6), Chihuahua (5).

Most co-reported drugs: Bedinvetmab (8 reports), Afoxolaner (7 reports), Butorphanol (5 reports), Maropitant Citrate (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.