Reaction profile

The FDA adverse-event record for muscle contracture

73 FDA adverse-event reports reference muscle contracture (VeDDRA 2468). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1551 of 2,481
by report volume (all reactions)
73
reports citing this reaction
17.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Muscle contracture has 73 reports now versus 72 in that prior snapshot: 1 more (1.4%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Muscle contracture changes

FDA AER · VeDDRA plate

Code 2468 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 73 reports
  • DEATH-ELEV 17.8%
  • MID-PACK #1551/2481
  • PHOTO-FINISH Depressed ocular refl…
  • SPECIES-DOG Dog · 51
  • DRUG-LEAD Bedinvetmab · 10
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Depressed ocular reflex (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Muscle contracture

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Depressed ocular refl… · near73MAGNESIUM HIGH, BLOOD · near73Mopey · near73Muscle contracture · this re…73Synovitis · near73Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Muscle contracture

What the FDA AER plate says about Muscle contracture

Signature read: report volume at 73 (#1551 of 2,481) is the standout scale stamp on Muscle contracture. Report volume sits in the middle third of the reaction corpus. 13 of 73 reports were death-coded (17.8% of named reports, not a population mortality rate). Nearest volume peer: Depressed ocular reflex (±0 reports). Lead species Dog (51). Lead co-reported drug Bedinvetmab (10).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bedinvetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 51
Cat 13
Horse 5
Human 3
Chicken 1

Breeds Most Affected

Domestic Shorthair 8
Crossbred Canine/dog 6
Chihuahua 5
Retriever - Labrador 4
Unknown 3
Greyhound 3
Spaniel - Cocker American 2
Pug 2
Shih Tzu 2
Boxer (German Boxer) 2

Associated Drugs

Bedinvetmab 10
Afoxolaner 7
Gabapentin 6
Butorphanol 5
Maropitant Citrate 5
Cefovecin 5
Fluralaner 13.64% 12-Week Chew 4
Tigilanol Tiglate 4
Propofol 3
Sarolaner 3
Clodronate Disodium 3
Buprenorphine 3
Alfaxalone 3
Midazolam 3
Hydromorphone 3
Grapiprant 3
Carprofen 3
Lufenuron + Milbemycin Oxime 2
Fluralaner/Moxidectin Spot-On 2
Lotilaner 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Muscle contracture, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (73 here).

Similar death-coded share

Nearest other reactions by death-coded share (17.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Muscle contracture (#1551 of 2,481 by report volume); death-coded 17.8%. PlainBreed reaction plate · report volume stamp 73 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →