Reaction profile

The FDA adverse-event record for mental confusion

246 FDA adverse-event reports reference mental confusion (VeDDRA 1609). See the species, breeds, and drugs most associated with it below.

246
reports citing this reaction
12.2%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
246
Total Reports
30
Deaths
12.2%
Death Rate

Species Most Affected

Dog 212
Human 16
Cat 14
Donkey 1
Horse 1
Other Equids 1
Other 1

Breeds Most Affected

Unknown 18
Crossbred Canine/dog 17
Retriever - Labrador 14
Shepherd Dog - German 10
Chihuahua 9
Domestic Shorthair 9
Pit Bull 7
Dog (unknown) 7
Beagle 7
Boxer (German Boxer) 7

Associated Drugs

Afoxolaner 38
Milbemycin Oxime + Spinosad 32
Ivermectin + Pyrantel As Pamoate Salt 22
Trilostane 19
Bedinvetmab 15
Oclacitinib Maleate 14
Pyrantel Pamoate;Sarolaner 12
Sarolaner 11
Fluralaner Chew Tablets 10
Lotilaner 10
Carprofen 9
Gabapentin 8
Fluralaner 13.64% 12-Week Chew 8
Moxidectin 6
Milbemycin Oxime + Praziquantel 6
Buprenorphine 5
Isoflurane 4
Spinosad 4
Prednisone 4
Pimobendan 4

Mental confusion Reaction Insights

246 reports name Mental confusion; 30 recorded a death outcome (12.2% of reported events, not a population-level mortality rate). VeDDRA code: 1609.

By species: Dog (212 reports), Human (16 reports), Cat (14 reports). By breed: Unknown (18), Crossbred Canine/dog (17), Retriever - Labrador (14).

Most co-reported drugs: Afoxolaner (38 reports), Milbemycin Oxime + Spinosad (32 reports), Ivermectin + Pyrantel As Pamoate Salt (22 reports), Trilostane (19 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.