Reaction profile

The FDA adverse-event record for mental confusion

257 FDA adverse-event reports reference mental confusion (VeDDRA 1609). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#925 of 2,481
by report volume (all reactions)
257
reports citing this reaction
12.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Mental confusion has 257 reports now versus 250 in that prior snapshot: 7 more (2.8%).

Report change
+7
Death-coded reports
+1
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Mental confusion changes

FDA AER · VeDDRA plate

Code 1609 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 257 reports
  • DEATH-ELEV 12.1%
  • MID-PACK #925/2481
  • PHOTO-FINISH Apathy
  • SPECIES-DOG Dog · 217
  • DRUG-LEAD Afoxolaner · 38
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Apathy (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Mental confusion

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Apathy · near257Injection site infect… · near257Injection site mucopu… · near257Injection site skin d… · near257Mental confusion · this reac…257Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Mental confusion

What the FDA AER plate says about Mental confusion

Signature read: report volume at 257 (#925 of 2,481) is the standout scale stamp on Mental confusion. Report volume sits in the middle third of the reaction corpus. 31 of 257 reports were death-coded (12.1% of named reports, not a population mortality rate). Nearest volume peer: Apathy (±0 reports). Lead species Dog (217). Lead co-reported drug Afoxolaner (38).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Afoxolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 217
Cat 20
Human 16
Donkey 1
Horse 1
Other Equids 1
Other 1

Breeds Most Affected

Unknown 18
Crossbred Canine/dog 17
Retriever - Labrador 14
Domestic Shorthair 14
Shepherd Dog - German 10
Chihuahua 9
Pit Bull 7
Dog (unknown) 7
Beagle 7
Boxer (German Boxer) 7

Associated Drugs

Afoxolaner 38
Milbemycin Oxime + Spinosad 32
Ivermectin + Pyrantel As Pamoate Salt 22
Trilostane 19
Bedinvetmab 16
Oclacitinib Maleate 14
Pyrantel Pamoate;Sarolaner 14
Gabapentin 11
Sarolaner 11
Carprofen 10
Fluralaner Chew Tablets 10
Lotilaner 10
Fluralaner 13.64% 12-Week Chew 8
Buprenorphine 7
Maropitant Citrate 7
Moxidectin 6
Phenobarbital 6
Milbemycin Oxime + Praziquantel 6
Fluid Therapy (Unknown) 5
Cefovecin 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Mental confusion, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (12.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Mental confusion (#925 of 2,481 by report volume); death-coded 12.1%. PlainBreed reaction plate · report volume stamp 257 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →