Reaction profile

The FDA adverse-event record for hiccup

122 FDA adverse-event reports reference hiccup (VeDDRA 2090). See the species, breeds, and drugs most associated with it below.

122
reports citing this reaction
3.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
122
Total Reports
4
Deaths
3.3%
Death Rate

Species Most Affected

Dog 111
Cat 9
Human 1
Goat 1

Breeds Most Affected

Crossbred Canine/dog 12
Retriever - Labrador 11
Beagle 6
Domestic Shorthair 6
Chihuahua 4
Shih Tzu 4
Retriever - Golden 4
Boxer (German Boxer) 4
Dog (unknown) 4
Shepherd Dog - German 3

Associated Drugs

Milbemycin Oxime + Spinosad 23
Sarolaner 11
Fluralaner Chew Tablets 10
Afoxolaner 10
Milbemycin Oxime + Praziquantel 6
Ivermectin + Pyrantel As Pamoate Salt 6
Milbemycin Oxime 4
Oclacitinib Maleate 4
Pyrantel Pamoate;Sarolaner 4
Fluralaner 13.64% 12-Week Chew 4
Nitenpyram 3
Imidacloprid + Moxidectin 3
Lotilaner 3
Gabapentin 3
Prednisone 2
Spinosad 2
Lufenuron + Milbemycin Oxime 2
Meloxicam 2
Pyrantel 2
Famotidine 2

Hiccup Reaction Insights

122 reports name Hiccup; 4 recorded a death outcome (3.3% of reported events, not a population-level mortality rate). VeDDRA code: 2090.

By species: Dog (111 reports), Cat (9 reports), Human (1 reports). By breed: Crossbred Canine/dog (12), Retriever - Labrador (11), Beagle (6).

Most co-reported drugs: Milbemycin Oxime + Spinosad (23 reports), Sarolaner (11 reports), Fluralaner Chew Tablets (10 reports), Afoxolaner (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.