Reaction profile

The FDA adverse-event record for hiccup

126 FDA adverse-event reports reference hiccup (VeDDRA 2090). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1282 of 2,481
by report volume (all reactions)
126
reports citing this reaction
3.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hiccup has 126 reports now versus 124 in that prior snapshot: 2 more (1.6%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hiccup changes

FDA AER · VeDDRA plate

Code 2090 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 126 reports
  • DEATH-LOW 3.2%
  • MID-PACK #1282/2481
  • PHOTO-FINISH Extensor rigidity
  • SPECIES-DOG Dog · 115
  • DRUG-LEAD Milbemycin Oxime… · 23
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Extensor rigidity (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Hiccup

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Extensor rigidity · near126Flatulence, bloating… · near126Hiccup · this reaction126Infertility NOS · near126Large platelets · near126Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hiccup

Hiccup: low death-coded share in the FDA AER plate

Signature read: Hiccup's 3.2% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 4 of 126 reports (3.2% of named reports). Nearest volume peer: Extensor rigidity (±0 reports). Lead species Dog (115). Lead co-reported drug Milbemycin Oxime + Spinosad (23).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 115
Cat 9
Human 1
Goat 1

Breeds Most Affected

Crossbred Canine/dog 12
Retriever - Labrador 11
Beagle 6
Domestic Shorthair 6
Shih Tzu 5
Chihuahua 4
Unknown 4
Retriever - Golden 4
Boxer (German Boxer) 4
Dog (unknown) 4

Associated Drugs

Milbemycin Oxime + Spinosad 23
Sarolaner 11
Fluralaner Chew Tablets 10
Afoxolaner 10
Milbemycin Oxime + Praziquantel 6
Ivermectin + Pyrantel As Pamoate Salt 6
Oclacitinib Maleate 5
Milbemycin Oxime 4
Lotilaner 4
Pyrantel Pamoate;Sarolaner 4
Fluralaner 13.64% 12-Week Chew 4
Nitenpyram 3
Imidacloprid + Moxidectin 3
Pyrantel Pamoate 3
Gabapentin 3
Spinosad 2
Prednisone 2
Meloxicam 2
Lufenuron + Milbemycin Oxime 2
Pyrantel 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hiccup, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (126 here).

Similar death-coded share

Nearest other reactions by death-coded share (3.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hiccup (#1282 of 2,481 by report volume); death-coded 3.2%. PlainBreed reaction plate · death-coded share stamp 3.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →