Reaction profile

The FDA adverse-event record for infertility nos

126 FDA adverse-event reports reference infertility nos (VeDDRA 764). See the species, breeds, and drugs most associated with it below.

126
reports citing this reaction
3.2%
death-coded share
Dog
most-affected species
Spinosad
most-associated drug
Verify with FDA CVM →
126
Total Reports
4
Deaths
3.2%
Death Rate

Species Most Affected

Dog 81
Cattle 29
Chicken 4
Goat 3
Horse 2
Human 2
Other Birds 1
Pig 1
Mouse 1
Sheep 1

Breeds Most Affected

Dog (unknown) 13
Holstein-Friesian also known as Holstein 7
Retriever - Golden 7
Cattle (unknown) 6
Bulldog 5
Aberdeen Angus 4
Chicken (unknown) 4
Retriever - Labrador 4
Crossbred Bovine/Cattle 3
Collie - Border 3

Associated Drugs

Spinosad 34
Milbemycin Oxime + Spinosad 18
Fluralaner Chew Tablets 14
Monensin Sodium 13
Ivermectin 7
Sometribove 6
Nitenpyram 6
Moxidectin 5
Milbemycin Oxime + Praziquantel 4
Fluralaner 13.64% 12-Week Chew 4
Narasin + Nicarbazin 3
Eprinomectin 5% Injection 3
Milbemycin Oxime 3
Oclacitinib Maleate 3
Milbemycin 2
Sometribove Zinc Suspension 2
Fenbendazole 2
Estradiol Benzoate, Progesterone 1
Tulathromycin 1
Cefpodoxime Proxetil 1

Infertility NOS Reaction Insights

126 reports name Infertility NOS; 4 recorded a death outcome (3.2% of reported events, not a population-level mortality rate). VeDDRA code: 764.

By species: Dog (81 reports), Cattle (29 reports), Chicken (4 reports). By breed: Dog (unknown) (13), Holstein-Friesian also known as Holstein (7), Retriever - Golden (7).

Most co-reported drugs: Spinosad (34 reports), Milbemycin Oxime + Spinosad (18 reports), Fluralaner Chew Tablets (14 reports), Monensin Sodium (13 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.