Reaction profile

The FDA adverse-event record for limping

2,549 FDA reports name limping, a high-volume reaction in the CVM extract (VeDDRA 1990). Plate stamps and neighbourhood peers follow.

#187 of 2,481
by report volume (all reactions)
2,549
reports citing this reaction
10.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Limping has 2,549 reports now versus 2,480 in that prior snapshot: 69 more (2.8%).

Report change
+69
Death-coded reports
+6
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Limping changes

FDA AER · VeDDRA plate

Code 1990 VOL-MID

VOL-MID · DEATH-ELEV · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,549 reports
  • DEATH-ELEV 10.2%
  • TOP-DECILE #187/2481
  • PHOTO-FINISH Application site eryt…
  • SPECIES-DOG Dog · 2,158
  • DRUG-LEAD Milbemycin Oxime… · 349
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site erythema (±7 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Limping

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Dermatitis · near2569Blindness · near2558Application site eryt… · near2556Limping · this reaction2549Systemic disorder NOS · near2540Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Limping

What the FDA AER plate says about Limping

Signature read: 2,549 reports place Limping in the upper third of FDA AER volume (#187 of 2,481). Report volume is upper-third scale: 2,549 named reports in the openFDA extract. 260 of 2,549 reports were death-coded (10.2% of named reports, not a population mortality rate). Nearest volume peer: Application site erythema (±7 reports). Lead species Dog (2,158). Lead co-reported drug Milbemycin Oxime + Spinosad (349).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 2,158
Cat 360
Cattle 11
Horse 7
Pig 4
Unknown 2
Sheep 1
Other 1
Goat 1
Guinea Pig 1

Breeds Most Affected

Retriever - Labrador 311
Domestic Shorthair 210
Crossbred Canine/dog 133
Shepherd Dog - German 127
Retriever - Golden 108
Chihuahua 63
Dog (unknown) 61
Pit Bull 61
Boxer (German Boxer) 59
Shepherd Dog - Australian 50

Associated Drugs

Milbemycin Oxime + Spinosad 349
Bedinvetmab 230
Carprofen 227
Gabapentin 184
Milbemycin Oxime + Praziquantel 160
Afoxolaner 138
Oclacitinib Maleate 125
Tigilanol Tiglate 117
Moxidectin 114
Lotilaner 111
Maropitant Citrate 104
Prednisone 101
Trilostane 85
Ivermectin + Pyrantel As Pamoate Salt 85
Frunevetmab 84
Grapiprant 81
Fluralaner Chew Tablets 79
Fluralaner 13.64% 12-Week Chew 76
Robenacoxib 70
Cefovecin 65

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Limping, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (2,549 here).

Similar death-coded share

Nearest other reactions by death-coded share (10.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Limping (#187 of 2,481 by report volume); death-coded 10.2%. PlainBreed reaction plate · report volume stamp 2,549 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →