Reaction profile

The FDA adverse-event record for limping

2,383 FDA adverse-event reports reference limping (VeDDRA 1990). See the species, breeds, and drugs most associated with it below.

2,383
reports citing this reaction
10.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
2,383
Total Reports
244
Deaths
10.2%
Death Rate

Species Most Affected

Dog 2,031
Cat 323
Cattle 10
Horse 6
Pig 4
Unknown 2
Sheep 1
Other 1
Goat 1
Mule 1

Breeds Most Affected

Retriever - Labrador 287
Domestic Shorthair 184
Crossbred Canine/dog 128
Shepherd Dog - German 117
Retriever - Golden 97
Pit Bull 60
Chihuahua 59
Dog (unknown) 58
Boxer (German Boxer) 56
Shepherd Dog - Australian 46

Associated Drugs

Milbemycin Oxime + Spinosad 349
Carprofen 202
Bedinvetmab 192
Gabapentin 162
Milbemycin Oxime + Praziquantel 152
Afoxolaner 135
Oclacitinib Maleate 115
Tigilanol Tiglate 110
Moxidectin 106
Lotilaner 97
Prednisone 92
Maropitant Citrate 91
Trilostane 83
Ivermectin + Pyrantel As Pamoate Salt 82
Fluralaner Chew Tablets 79
Grapiprant 75
Frunevetmab 68
Fluralaner 13.64% 12-Week Chew 67
Robenacoxib 61
Cefovecin 60

Limping Reaction Insights

2,383 reports name Limping; 244 recorded a death outcome (10.2% of reported events, not a population-level mortality rate). VeDDRA code: 1990.

By species: Dog (2,031 reports), Cat (323 reports), Cattle (10 reports). By breed: Retriever - Labrador (287), Domestic Shorthair (184), Crossbred Canine/dog (128).

Most co-reported drugs: Milbemycin Oxime + Spinosad (349 reports), Carprofen (202 reports), Bedinvetmab (192 reports), Gabapentin (162 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.