Reaction profile

The FDA adverse-event record for large platelets

109 FDA adverse-event reports reference large platelets (VeDDRA 2425). See the species, breeds, and drugs most associated with it below.

109
reports citing this reaction
24.8%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
109
Total Reports
27
Deaths
24.8%
Death Rate

Species Most Affected

Dog 107
Cat 2

Breeds Most Affected

Retriever - Labrador 17
Crossbred Canine/dog 11
Retriever - Golden 9
Dachshund (unspecified) 6
Terrier (unspecified) 5
Poodle (unspecified) 5
Spaniel - King Charles Cavalier 4
Shepherd Dog - Australian 4
Chihuahua 3
Boxer (German Boxer) 3

Associated Drugs

Carprofen 33
Fluralaner 13.64% 12-Week Chew 17
Verdinexor 10
Maropitant Citrate 9
Metronidazole 8
Prednisone 8
Gabapentin 8
Maropitant 7
Butorphanol 7
Milbemycin Oxime + Spinosad 6
Doxycycline 6
Enrofloxacin 6
Isoflurane 6
Bedinvetmab 6
Polysulfated Glycosaminoglycan 5
Fluralaner Chew Tablets 5
Afoxolaner 5
Propofol 5
Capromorelin 5
Dexmedetomidine 5

Large platelets Reaction Insights

109 reports name Large platelets; 27 recorded a death outcome (24.8% of reported events, not a population-level mortality rate). VeDDRA code: 2425.

By species: Dog (107 reports), Cat (2 reports). By breed: Retriever - Labrador (17), Crossbred Canine/dog (11), Retriever - Golden (9).

Most co-reported drugs: Carprofen (33 reports), Fluralaner 13.64% 12-Week Chew (17 reports), Verdinexor (10 reports), Maropitant Citrate (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.