Reaction profile

The FDA adverse-event record for decreased mean corpuscular haemoglobin concentration (mchc)

58 FDA adverse-event reports reference decreased mean corpuscular haemoglobin concentration (mchc) (VeDDRA 3090). See the species, breeds, and drugs most associated with it below.

58
reports citing this reaction
13.8%
death-coded share
Dog
most-affected species
Eprinomectin + Esafoxolaner + Praziquantel
most-associated drug
Verify with FDA CVM →
58
Total Reports
8
Deaths
13.8%
Death Rate

Species Most Affected

Dog 42
Cat 14
Horse 2

Breeds Most Affected

Domestic Shorthair 9
Retriever - Labrador 6
Shih Tzu 3
Shepherd Dog - Australian 2
Terrier - Bull - American Pit 2
Pit Bull 2
Terrier - Yorkshire 2
Boxer (German Boxer) 2
Crossbred Canine/dog 1
Retriever - Golden 1

Associated Drugs

Eprinomectin + Esafoxolaner + Praziquantel 6
Oclacitinib Maleate 6
Gabapentin 5
Ilunocitinib 5
Maropitant Citrate 4
Afoxolaner 4
Doxycycline 4
Bedinvetmab 4
Ivermectin + Pyrantel As Pamoate Salt 3
Estriol Tablets 3
Fluralaner 3
Melarsomine 3
Prednisone 3
Milbemycin Oxime + Praziquantel 3
Meloxicam 3
Fluralaner 13.64% 12-Week Chew 3
Midazolam 3
Carprofen 3
Fuzapladib Sodium 2
Maropitant 2

Decreased mean corpuscular haemoglobin concentration (MCHC) Reaction Insights

58 reports name Decreased mean corpuscular haemoglobin concentration (MCHC); 8 recorded a death outcome (13.8% of reported events, not a population-level mortality rate). VeDDRA code: 3090.

By species: Dog (42 reports), Cat (14 reports), Horse (2 reports). By breed: Domestic Shorthair (9), Retriever - Labrador (6), Shih Tzu (3).

Most co-reported drugs: Eprinomectin + Esafoxolaner + Praziquantel (6 reports), Oclacitinib Maleate (6 reports), Gabapentin (5 reports), Ilunocitinib (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.