Reaction profile

The FDA adverse-event record for missing labels

466 FDA reports name missing labels, a high-volume reaction in the CVM extract (VeDDRA 99017). Plate stamps and neighbourhood peers follow.

#668 of 2,481
by report volume (all reactions)
466
reports citing this reaction
0.2%
death-coded share
Unknown
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Missing Labels has 466 reports now versus 451 in that prior snapshot: 15 more (3.3%).

Report change
+15
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Missing Labels changes

FDA AER · VeDDRA plate

Code 99017 VOL-LOW

VOL-LOW · DEATH-RARE · MID-PACK · PHOTO-FINISH · SPECIES-UNKNOWN · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 466 reports
  • DEATH-RARE 0.2%
  • MID-PACK #668/2481
  • PHOTO-FINISH Alkaline urine
  • SPECIES-UNKNOWN Unknown · 448
  • DRUG-LEAD Milbemycin Oxime… · 45
  • DESK-WIDE 16 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Alkaline urine (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Missing Labels

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Appetite disorder NOS · near468Missing Labels · this reacti…466Alkaline urine · near465Ear pain · near465INEFFECTIVE, WORMS · near465Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Missing Labels

Missing Labels: low death-coded share in the FDA AER plate

Signature read: Missing Labels's 0.2% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is upper-third scale: 466 named reports in the openFDA extract. Death-coded share is lower-third: 1 of 466 reports (0.2% of named reports). Nearest volume peer: Alkaline urine (±1 reports). Lead species Unknown (448). Lead co-reported drug Milbemycin Oxime + Praziquantel (45).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Praziquantel appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Unknown 448
Dog 14
Cattle 3
Cat 1

Breeds Most Affected

Unknown 448
Dalmatian 2
Spaniel - Cocker American 2
Crossbred Canine/dog 2
Retriever - Labrador 1
Mixed (Cattle) 1
Brangus 1
Bulldog - American 1
Domestic Longhair 1
Schnauzer - Miniature 1

Associated Drugs

Milbemycin Oxime + Praziquantel 45
Imidacloprid 42
Selamectin 34
Ivermectin + Pyrantel As Pamoate Salt 21
Nitenpyram 18
Afoxolaner 16
Carprofen 12
Fluralaner 13.64% 12-Week Chew 12
Lotilaner 12
Imidacloprid + Moxidectin 10
Meloxicam 10
Enrofloxacin 9
Penicillin G Procaine 8
Milbemycin Oxime + Spinosad 7
Sarolaner 7
Moxidectin 6
Fluralaner Spot-On Solution 6
Gonadorelindiacetate Tetrahydrate Injection 5
Ivermectin + Pyrantel 5
Oclacitinib Maleate 5

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Missing Labels, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (466 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Missing Labels (#668 of 2,481 by report volume); death-coded 0.2%. PlainBreed reaction plate · death-coded share stamp 0.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →