Reaction profile

The FDA adverse-event record for lack of efficacy (ectoparasite) - mite nos

280 FDA adverse-event reports reference lack of efficacy (ectoparasite) - mite nos (VeDDRA 2652). See the species, breeds, and drugs most associated with it below.

280
reports citing this reaction
1.8%
death-coded share
Dog
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
280
Total Reports
5
Deaths
1.8%
Death Rate

Species Most Affected

Dog 130
Cattle 70
Cat 66
Pig 7
Rabbit 4
Guinea Pig 1
Sheep 1
Ferret 1

Breeds Most Affected

Dog (unknown) 39
Holstein-Friesian also known as Holstein 26
Domestic Shorthair 21
Cattle (unknown) 17
Cat (other) 17
Cat (unknown) 13
Crossbred Canine/dog 10
Retriever - Labrador 8
Shepherd Dog - German 8
Cattle (other) 8

Associated Drugs

Selamectin 61
Fluralaner 13.64% 12-Week Chew 30
Afoxolaner 22
Eprinomectin 20
Ivermectin 19
Fluralaner Spot-On Solution 15
Pyrantel Pamoate;Sarolaner 13
Eprinomectin 5 Mg/Ml Pour-On Solution 12
Selamectin;Sarolaner 12
Moxidectin 10
Doramectin 7
Imidacloprid + Moxidectin 6
Lotilaner 6
Spinosad 4
Eprinomectin 0.5% Pour-On 4
Ivermectin 0.5% Pour-On Topical Solution 4
Milbemycin Oxime 4
Fluralaner 5.46% 1-Month Chew 4
Eprinomectin Topical 3
Ivermectin 0.5% Pour-On 3

Lack of efficacy (ectoparasite) - mite NOS Reaction Insights

280 reports name Lack of efficacy (ectoparasite) - mite NOS; 5 recorded a death outcome (1.8% of reported events, not a population-level mortality rate). VeDDRA code: 2652.

By species: Dog (130 reports), Cattle (70 reports), Cat (66 reports). By breed: Dog (unknown) (39), Holstein-Friesian also known as Holstein (26), Domestic Shorthair (21).

Most co-reported drugs: Selamectin (61 reports), Fluralaner 13.64% 12-Week Chew (30 reports), Afoxolaner (22 reports), Eprinomectin (20 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.