Reaction profile

The FDA adverse-event record for chewing - pruritus (see also 'oral cavity disorders')

478 FDA adverse-event reports reference chewing - pruritus (see also 'oral cavity disorders') (VeDDRA 2618). See the species, breeds, and drugs most associated with it below.

478
reports citing this reaction
1.9%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
478
Total Reports
9
Deaths
1.9%
Death Rate

Species Most Affected

Dog 402
Cat 73
Guinea Pig 1
Ferret 1
Cattle 1

Breeds Most Affected

Domestic Shorthair 44
Crossbred Canine/dog 33
Retriever - Labrador 27
Shepherd Dog - German 26
Chihuahua 25
Terrier - Yorkshire 19
Retriever - Golden 19
Dog (unknown) 14
Maltese 13
Shih Tzu 13

Associated Drugs

Afoxolaner 56
Fluralaner Chew Tablets 50
Pyrantel Pamoate;Sarolaner 48
Imidacloprid + Moxidectin 41
Nitenpyram 29
Fluralaner 13.64% 12-Week Chew 29
Ivermectin + Pyrantel As Pamoate Salt 23
Flumethrin-Imidacloprid 20
Moxidectin 20
Selamectin 19
Sarolaner 19
Fluralaner Spot-On Solution 17
Shampoo 17
Carprofen 14
Trilostane 13
Oclacitinib Maleate 13
Milbemycin Oxime + Spinosad 12
Prednisone 11
Lotilaner 11
Diphenhydramine 10

Chewing - pruritus (see also 'Oral cavity disorders') Reaction Insights

478 reports name Chewing - pruritus (see also 'Oral cavity disorders'); 9 recorded a death outcome (1.9% of reported events, not a population-level mortality rate). VeDDRA code: 2618.

By species: Dog (402 reports), Cat (73 reports), Guinea Pig (1 reports). By breed: Domestic Shorthair (44), Crossbred Canine/dog (33), Retriever - Labrador (27).

Most co-reported drugs: Afoxolaner (56 reports), Fluralaner Chew Tablets (50 reports), Pyrantel Pamoate;Sarolaner (48 reports), Imidacloprid + Moxidectin (41 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.