Reaction profile

The FDA adverse-event record for lack of efficacy (bacteria) - ehrlichia

2,922 FDA reports name lack of efficacy (bacteria) - ehrlichia, a high-volume reaction in the CVM extract (VeDDRA 2805). Plate stamps and neighbourhood peers follow.

#160 of 2,481
by report volume (all reactions)
2,922
reports citing this reaction
0.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of efficacy (bacteria) - Ehrlichia has 2,922 reports now versus 2,761 in that prior snapshot: 161 more (5.8%).

Report change
+161
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of efficacy (bacteria) - Ehrlichia changes

FDA AER · VeDDRA plate

Code 2805 VOL-MID

VOL-MID · DEATH-RARE · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,922 reports
  • DEATH-RARE 0.8%
  • TOP-DECILE #160/2481
  • PHOTO-FINISH Drug dose administrat…
  • SPECIES-DOG Dog · 2,918
  • DRUG-LEAD Pyrantel Pamoate;… · 1,264
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Drug dose administration interval too short (±30 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Lack of efficacy - Ehrlichia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Hard, clumping · near2964Lack of efficacy (bac… · thi…2922Drug dose administrat… · near2892Skin scab · near2891Vials, Leaking · near2887Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lack of efficacy (bacteria) - Ehrlichia

Lack of efficacy (bacteria) - Ehrlichia: low death-coded share in the FDA AER plate

Signature read: 2,922 reports place Lack of efficacy (bacteria) - Ehrlichia in the upper third of FDA AER volume (#160 of 2,481). Report volume is upper-third scale: 2,922 named reports in the openFDA extract. Death-coded share is lower-third: 24 of 2,922 reports (0.8% of named reports). Nearest volume peer: Drug dose administration interval too short (±30 reports). Lead species Dog (2,918). Lead co-reported drug Pyrantel Pamoate;Sarolaner (1,264).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Pyrantel Pamoate;Sarolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 2,918
Cat 3
Horse 1

Breeds Most Affected

Retriever - Labrador 401
Crossbred Canine/dog 316
Retriever - Golden 220
Dog (unknown) 219
Shepherd Dog - German 205
Shepherd Dog - Australian 112
Beagle 80
Great Pyrenees 72
Terrier (unspecified) 54
Hound (unspecified) 50

Associated Drugs

Pyrantel Pamoate;Sarolaner 1,264
Afoxolaner 646
Fluralaner 13.64% 12-Week Chew 594
Sarolaner 152
Lotilaner 148
Ivermectin + Pyrantel As Pamoate Salt 88
Milbemycin Oxime + Praziquantel 72
Fluralaner 5.46% 1-Month Chew 65
Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 54
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 49
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 27
Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet 25
Milbemycin/Lufenuron/Pzq Chew 22
Recombitek Lyme - 2126.R0 18
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 18
Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate 16
Fluralaner 13
Fluralaner Spot-On Solution 13
Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 11
Doxycycline 11

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lack of efficacy (bacteria) - Ehrlichia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (2,922 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of efficacy (bacteria) - Ehrlichia (#160 of 2,481 by report volume); death-coded 0.8%. PlainBreed reaction plate · report volume stamp 2,922 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →