Reaction profile

The FDA adverse-event record for lack of efficacy (bacteria) - ehrlichia

2,539 FDA adverse-event reports reference lack of efficacy (bacteria) - ehrlichia (VeDDRA 2805). See the species, breeds, and drugs most associated with it below.

2,539
reports citing this reaction
0.8%
death-coded share
Dog
most-affected species
Pyrantel Pamoate;Sarolaner
most-associated drug
Verify with FDA CVM →
2,539
Total Reports
21
Deaths
0.8%
Death Rate

Species Most Affected

Dog 2,535
Cat 3
Horse 1

Breeds Most Affected

Retriever - Labrador 348
Crossbred Canine/dog 273
Dog (unknown) 200
Retriever - Golden 188
Shepherd Dog - German 177
Shepherd Dog - Australian 106
Beagle 71
Great Pyrenees 59
Terrier (unspecified) 47
Collie - Border 43

Associated Drugs

Pyrantel Pamoate;Sarolaner 1,095
Afoxolaner 596
Fluralaner 13.64% 12-Week Chew 522
Sarolaner 141
Lotilaner 135
Ivermectin + Pyrantel As Pamoate Salt 64
Milbemycin Oxime + Praziquantel 59
Fluralaner 5.46% 1-Month Chew 56
Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 38
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 26
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 22
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 18
Milbemycin/Lufenuron/Pzq Chew 15
Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet 15
Recombitek Lyme - 2126.R0 13
Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 11
Fluralaner Spot-On Solution 11
Doxycycline 9
Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet 9
Fluralaner 8

Lack of efficacy (bacteria) - Ehrlichia Reaction Insights

2,539 reports name Lack of efficacy (bacteria) - Ehrlichia; 21 recorded a death outcome (0.8% of reported events, not a population-level mortality rate). VeDDRA code: 2805.

By species: Dog (2,535 reports), Cat (3 reports), Horse (1 reports). By breed: Retriever - Labrador (348), Crossbred Canine/dog (273), Dog (unknown) (200).

Most co-reported drugs: Pyrantel Pamoate;Sarolaner (1,095 reports), Afoxolaner (596 reports), Fluralaner 13.64% 12-Week Chew (522 reports), Sarolaner (141 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.