Reaction profile

The FDA adverse-event record for drug dose administration interval too short

2,892 FDA reports name drug dose administration interval too short, a high-volume reaction in the CVM extract (VeDDRA 99824). Plate stamps and neighbourhood peers follow.

#161 of 2,481
by report volume (all reactions)
2,892
reports citing this reaction
1.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Drug dose administration interval too short has 2,892 reports now versus 2,821 in that prior snapshot: 71 more (2.5%).

Report change
+71
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Drug dose administration interval too short changes

FDA AER · VeDDRA plate

Code 99824 VOL-MID

VOL-MID · DEATH-LOW · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,892 reports
  • DEATH-LOW 1.4%
  • TOP-DECILE #161/2481
  • PHOTO-FINISH Skin scab
  • SPECIES-DOG Dog · 2,338
  • DRUG-LEAD Selamectin · 396
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Skin scab (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Drug dose administration interval too short

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Lack of efficacy (bac… · near2922Drug dose administrat… · thi…2892Skin scab · near2891Vials, Leaking · near2887Unclassifiable advers… · near2876Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Drug dose administration interval too short

Drug dose administration interval too short: low death-coded share in the FDA AER plate

Signature read: 2,892 reports place Drug dose administration interval too short in the upper third of FDA AER volume (#161 of 2,481). Report volume is upper-third scale: 2,892 named reports in the openFDA extract. Death-coded share is lower-third: 40 of 2,892 reports (1.4% of named reports). Nearest volume peer: Skin scab (±1 reports). Lead species Dog (2,338). Lead co-reported drug Selamectin (396).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Selamectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 2,338
Cat 516
Cattle 24
Horse 8
Ferret 3
Pig 1
Rabbit 1
Unknown 1

Breeds Most Affected

Domestic Shorthair 274
Retriever - Labrador 219
Crossbred Canine/dog 171
Dog (unknown) 130
Chihuahua 119
Terrier - Yorkshire 97
Retriever - Golden 92
Shepherd Dog - German 88
Shih Tzu 85
Cat (unknown) 67

Associated Drugs

Selamectin 396
Moxidectin 349
Spinosad 247
Imidacloprid + Moxidectin 227
Fluralaner 13.64% 12-Week Chew 183
Milbemycin Oxime + Spinosad 169
Afoxolaner 143
Fluralaner Chew Tablets 134
Trilostane 107
Nitenpyram 89
Ivermectin + Pyrantel As Pamoate Salt 83
Fluralaner Spot-On Solution 80
Milbemycin Oxime + Praziquantel 61
Oclacitinib Maleate 53
Sarolaner 50
Genta/Momet/Clotrim Ear Oint 41
Emodepside + Praziquantel 40
Ivermectin 36
Insulin Injectable Vial 33
Pyrantel Pamoate;Sarolaner 33

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Drug dose administration interval too short, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (1.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Drug dose administration interval too short (#161 of 2,481 by report volume); death-coded 1.4%. PlainBreed reaction plate · report volume stamp 2,892 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →