Reaction profile

The FDA adverse-event record for drug dose administration interval too short

2,758 FDA adverse-event reports reference drug dose administration interval too short (VeDDRA 99824). See the species, breeds, and drugs most associated with it below.

2,758
reports citing this reaction
1.4%
death-coded share
Dog
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
2,758
Total Reports
39
Deaths
1.4%
Death Rate

Species Most Affected

Dog 2,224
Cat 497
Cattle 24
Horse 8
Ferret 3
Pig 1
Rabbit 1

Breeds Most Affected

Domestic Shorthair 258
Retriever - Labrador 207
Crossbred Canine/dog 162
Dog (unknown) 126
Chihuahua 113
Terrier - Yorkshire 96
Retriever - Golden 87
Shepherd Dog - German 83
Shih Tzu 82
Cat (unknown) 67

Associated Drugs

Selamectin 395
Moxidectin 306
Spinosad 247
Imidacloprid + Moxidectin 224
Milbemycin Oxime + Spinosad 166
Fluralaner 13.64% 12-Week Chew 160
Afoxolaner 138
Fluralaner Chew Tablets 134
Trilostane 106
Nitenpyram 80
Ivermectin + Pyrantel As Pamoate Salt 80
Fluralaner Spot-On Solution 75
Milbemycin Oxime + Praziquantel 60
Oclacitinib Maleate 53
Sarolaner 48
Genta/Momet/Clotrim Ear Oint 41
Emodepside + Praziquantel 38
Ivermectin 36
Insulin Injectable Vial 32
Doxycycline 30

Drug dose administration interval too short Reaction Insights

2,758 reports name Drug dose administration interval too short; 39 recorded a death outcome (1.4% of reported events, not a population-level mortality rate). VeDDRA code: 99824.

By species: Dog (2,224 reports), Cat (497 reports), Cattle (24 reports). By breed: Domestic Shorthair (258), Retriever - Labrador (207), Crossbred Canine/dog (162).

Most co-reported drugs: Selamectin (395 reports), Moxidectin (306 reports), Spinosad (247 reports), Imidacloprid + Moxidectin (224 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.