Reaction profile

The FDA adverse-event record for allergic pruritus

368 FDA adverse-event reports reference allergic pruritus (VeDDRA 2076). See the species, breeds, and drugs most associated with it below.

368
reports citing this reaction
0.8%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
368
Total Reports
3
Deaths
0.8%
Death Rate

Species Most Affected

Dog 345
Cat 11
Horse 5
Human 5
Cattle 2

Breeds Most Affected

Retriever - Labrador 42
Chihuahua 18
Retriever - Golden 15
Terrier - Bull - American Pit 14
Shih Tzu 13
Dachshund (unspecified) 12
Crossbred Canine/dog 12
Shepherd Dog - German 12
Boxer (German Boxer) 10
Domestic Shorthair 9

Associated Drugs

Moxidectin 114
Cyclosporine A 104
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 17
Rabies Virus, 15
Milbemycin Oxime + Spinosad 11
Maropitant Citrate 11
Oclacitinib Maleate 10
Fluralaner Chew Tablets 10
Anti-Il31 Mab Mcs Lot #1283563 10
Afoxolaner 136 Mg Chewable Tablets 9
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 9
Prednisone 8
Afoxolaner 8
Diphenhydramine 7
Milbemycin Oxime + Praziquantel 7
Cephalexin 6
Cyclosporine 6
Canine Parvovirus Strain Nl-35-D, P.35-D, 8-2-80;Canine Parainfluenza Virus, Str 6
Hydroxyzine 5
Dexamethasone 5

Allergic pruritus Reaction Insights

368 reports name Allergic pruritus; 3 recorded a death outcome (0.8% of reported events, not a population-level mortality rate). VeDDRA code: 2076.

By species: Dog (345 reports), Cat (11 reports), Horse (5 reports). By breed: Retriever - Labrador (42), Chihuahua (18), Retriever - Golden (15).

Most co-reported drugs: Moxidectin (114 reports), Cyclosporine A (104 reports), Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str (17 reports), Rabies Virus, (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.