Reaction profile

The FDA adverse-event record for lack of efficacy (bacteria) - leptospira

62 FDA adverse-event reports reference lack of efficacy (bacteria) - leptospira (VeDDRA 2787). See the species, breeds, and drugs most associated with it below.

62
reports citing this reaction
37.1%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
62
Total Reports
23
Deaths
37.1%
Death Rate

Species Most Affected

Dog 61
Cattle 1

Breeds Most Affected

Shepherd Dog - German 5
Terrier (unspecified) 4
Shepherd Dog - Australian 4
Retriever - Labrador 3
Retriever - Golden 3
Catahoula Leopard Dog 3
Shih Tzu 2
Sheepdog - Shetland 2
Spaniel - King Charles Cavalier 2
Pointing Dog - Hungarian Short-haired (Vizsla) 2

Associated Drugs

Maropitant Citrate 28
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 22
Doxycycline 14
Metronidazole 9
Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 9
Enrofloxacin 8
Capromorelin Tartrate 8
Milbemycin Oxime + Praziquantel 7
Leptospirosis Vaccine 7
Fluid Therapy 7
Capromorelin 7
Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain 7
Lotilaner 6
Carprofen 6
Dextrose 6
Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 6
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str 6
Moxidectin 5
Gabapentin 5
Leptospira-Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 5

Lack of efficacy (bacteria) - Leptospira Reaction Insights

62 reports name Lack of efficacy (bacteria) - Leptospira; 23 recorded a death outcome (37.1% of reported events, not a population-level mortality rate). VeDDRA code: 2787.

By species: Dog (61 reports), Cattle (1 reports). By breed: Shepherd Dog - German (5), Terrier (unspecified) (4), Shepherd Dog - Australian (4).

Most co-reported drugs: Maropitant Citrate (28 reports), Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str (22 reports), Doxycycline (14 reports), Metronidazole (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.