Reaction profile

The FDA adverse-event record for diabetic ketoacidosis

576 FDA adverse-event reports reference diabetic ketoacidosis (VeDDRA 2053). See the species, breeds, and drugs most associated with it below.

576
reports citing this reaction
42.2%
death-coded share
Cat
most-affected species
Bexagliflozin
most-associated drug
Verify with FDA CVM →
576
Total Reports
243
Deaths
42.2%
Death Rate

Species Most Affected

Cat 416
Dog 160

Breeds Most Affected

Domestic Shorthair 268
Cat (unknown) 49
Domestic Mediumhair 32
Domestic Longhair 31
Crossbred Canine/dog 18
Retriever - Labrador 13
Maltese 9
Siamese 9
Poodle - Miniature 8
Terrier - Yorkshire 7

Associated Drugs

Bexagliflozin 240
Velagliflozin Proline Monohydrate 136
Trilostane 65
Insulin 49
Maropitant Citrate 45
Fluid Therapy 25
Dextrose 24
Gabapentin 20
Recombinant Human Insulin 19
Milbemycin Oxime + Spinosad 16
Prescription Diet 16
Bedinvetmab 15
Mirtazapine 14
Cefovecin Sodium 14
Carprofen 12
Insulin Injectable Vial 12
Buprenorphine 11
Insulin Glargine 11
Senvelgo Velagliflozin Oral Solution 11
Prednisone 10

Diabetic ketoacidosis Reaction Insights

576 reports name Diabetic ketoacidosis; 243 recorded a death outcome (42.2% of reported events, not a population-level mortality rate). VeDDRA code: 2053.

By species: Cat (416 reports), Dog (160 reports). By breed: Domestic Shorthair (268), Cat (unknown) (49), Domestic Mediumhair (32).

Most co-reported drugs: Bexagliflozin (240 reports), Velagliflozin Proline Monohydrate (136 reports), Trilostane (65 reports), Insulin (49 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.