Reaction profile

The FDA adverse-event record for diabetic ketoacidosis

631 FDA reports name diabetic ketoacidosis, a high-volume reaction in the CVM extract (VeDDRA 2053). Plate stamps and neighbourhood peers follow.

#557 of 2,481
by report volume (all reactions)
631
reports citing this reaction
42.0%
death-coded share
Cat
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Diabetic ketoacidosis has 631 reports now versus 609 in that prior snapshot: 22 more (3.6%).

Report change
+22
Death-coded reports
+5
Death-coded share
−0.7 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Diabetic ketoacidosis changes

FDA AER · VeDDRA plate

Code 2053 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-CAT · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 631 reports
  • DEATH-HOT 42.0%
  • UPPER-Q #557/2481
  • PHOTO-FINISH Vials, Abnormal
  • SPECIES-CAT Cat · 464
  • DRUG-LEAD Bexagliflozin · 268
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Vials, Abnormal (±1 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Diabetic ketoacidosis

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Weak pulse · near635Abdominal mass · near633Vials, Abnormal · near632Diabetic ketoacidosis · this…631Muscle spasm NOS · near628Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Diabetic ketoacidosis

Diabetic ketoacidosis: high death-coded share in the FDA AER plate

Signature read: 265 death-coded reports is a heavy tail count for Diabetic ketoacidosis in the CVM extract. Report volume is upper-third scale: 631 named reports in the openFDA extract. Death-coded share is upper-third: 265 of 631 reports (42.0% of named reports). Nearest volume peer: Vials, Abnormal (±1 reports). Lead species Cat (464). Lead co-reported drug Bexagliflozin (268).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cat 464
Dog 167

Breeds Most Affected

Domestic Shorthair 297
Cat (unknown) 57
Domestic Mediumhair 36
Domestic Longhair 35
Crossbred Canine/dog 18
Retriever - Labrador 15
Siamese 10
Maltese 9
Poodle - Miniature 8
Terrier - Yorkshire 7

Associated Drugs

Bexagliflozin 268
Velagliflozin Proline Monohydrate 155
Trilostane 65
Insulin 53
Maropitant Citrate 48
Fluid Therapy 27
Dextrose 25
Gabapentin 25
Recombinant Human Insulin 19
Prescription Diet 18
Milbemycin Oxime + Spinosad 16
Bedinvetmab 16
Mirtazapine 14
Cefovecin Sodium 14
Carprofen 12
Prednisone 12
Insulin Injectable Vial 12
Buprenorphine 12
Cefovecin 11
Famotidine 11

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Diabetic ketoacidosis, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (631 here).

Similar death-coded share

Nearest other reactions by death-coded share (42.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Diabetic ketoacidosis (#557 of 2,481 by report volume); death-coded 42.0%. PlainBreed reaction plate · death-coded report count stamp 265 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →