Reaction profile

The FDA adverse-event record for injection site crust

100 FDA adverse-event reports reference injection site crust (VeDDRA 87). See the species, breeds, and drugs most associated with it below.

100
reports citing this reaction
3.0%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
100
Total Reports
3
Deaths
3.0%
Death Rate

Species Most Affected

Dog 73
Cat 24
Goat 1
Horse 1
Mouse 1

Breeds Most Affected

Domestic Shorthair 17
Beagle 5
Retriever - Labrador 4
Domestic Longhair 4
Retriever - Golden 4
Crossbred Canine/dog 3
Shepherd Dog - German 3
Collie - Border 3
Dog (unknown) 3
Chihuahua 3

Associated Drugs

Tigilanol Tiglate 18
Carprofen 15
Diphenhydramine 14
Gabapentin 11
Cefovecin 10
Maropitant Citrate 10
Unspecified 10
Famotidine 9
Prednisone 9
Bedinvetmab 9
Meloxicam 8
Frunevetmab 8
Isoflurane 6
Moxidectin 6
Butorphanol Tartrate 6
Propofol 5
Anesthetic 4
Oclacitinib Maleate 4
Milbemycin Oxime + Praziquantel 4
Praziquantel 3

Injection site crust Reaction Insights

100 reports name Injection site crust; 3 recorded a death outcome (3.0% of reported events, not a population-level mortality rate). VeDDRA code: 87.

By species: Dog (73 reports), Cat (24 reports), Goat (1 reports). By breed: Domestic Shorthair (17), Beagle (5), Retriever - Labrador (4).

Most co-reported drugs: Tigilanol Tiglate (18 reports), Carprofen (15 reports), Diphenhydramine (14 reports), Gabapentin (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.