Reaction profile

The FDA adverse-event record for injection site crust

107 FDA adverse-event reports reference injection site crust (VeDDRA 87). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1356 of 2,481
by report volume (all reactions)
107
reports citing this reaction
2.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Injection site crust has 107 reports now versus 105 in that prior snapshot: 2 more (1.9%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Injection site crust changes

FDA AER · VeDDRA plate

Code 87 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 107 reports
  • DEATH-LOW 2.8%
  • MID-PACK #1356/2481
  • PHOTO-FINISH Gel/Paste, Abnormal
  • SPECIES-DOG Dog · 78
  • DRUG-LEAD Tigilanol Tiglate · 19
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Gel/Paste, Abnormal (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Injection site crust

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Acid-base disorder · near108Gel/Paste, Abnormal · near107Injection site crust · this …107Lack of efficacy, med… · near107Reduced conception ra… · near107Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Injection site crust

Injection site crust: low death-coded share in the FDA AER plate

Signature read: Injection site crust's 2.8% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 3 of 107 reports (2.8% of named reports). Nearest volume peer: Gel/Paste, Abnormal (±0 reports). Lead species Dog (78). Lead co-reported drug Tigilanol Tiglate (19).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Tigilanol Tiglate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 78
Cat 26
Goat 1
Horse 1
Mouse 1

Breeds Most Affected

Domestic Shorthair 19
Beagle 5
Retriever - Labrador 4
Domestic Longhair 4
Retriever - Golden 4
Shepherd Dog - German 4
Chihuahua 4
Maltese 4
Dachshund (unspecified) 4
Crossbred Canine/dog 3

Associated Drugs

Tigilanol Tiglate 19
Carprofen 16
Diphenhydramine 14
Maropitant Citrate 11
Gabapentin 11
Cefovecin 10
Unspecified 10
Meloxicam 9
Famotidine 9
Prednisone 9
Bedinvetmab 9
Frunevetmab 8
Moxidectin 7
Isoflurane 6
Propofol 6
Butorphanol Tartrate 6
Anesthetic 4
Buprenorphine 4
Ketamine 4
Oclacitinib Maleate 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Injection site crust, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (2.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Injection site crust (#1356 of 2,481 by report volume); death-coded 2.8%. PlainBreed reaction plate · death-coded share stamp 2.8% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →