Reaction profile

The FDA adverse-event record for reduced conception rate

105 FDA adverse-event reports reference reduced conception rate (VeDDRA 1163). See the species, breeds, and drugs most associated with it below.

105
reports citing this reaction
3.8%
death-coded share
Cattle
most-affected species
Sometribove
most-associated drug
Verify with FDA CVM →
105
Total Reports
4
Deaths
3.8%
Death Rate

Species Most Affected

Cattle 56
Dog 39
Pig 4
Sheep 4
Horse 1
Deer 1

Breeds Most Affected

Holstein-Friesian also known as Holstein 24
Retriever - Golden 13
Mixed (Cattle) 8
Aberdeen Angus 7
Cattle (other) 6
Jersey 5
Terrier - Scottish 4
Dog (unknown) 4
Pig (unknown) 2
Terrier - Silky 2

Associated Drugs

Sometribove 17
Monensin Sodium 16
Spinosad 15
Imidacloprid + Moxidectin 11
Milbemycin Oxime + Spinosad 8
Progesterone 7
Albendazole 7
Sometribove Zinc Suspension 6
Dinoprost Tromethamine 4
Pregnyl/Gestyl 200/400 4
Eprinomectin 4
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 4
Melengestrol Acetate 3
Gonadorelin Hydrochloride 3
Heartworm Prevention (Unknown) 2
Bovine Respiratory Syncytial Virus, 597-10 10Th Psg Strain 375; Bovine Viral Dia 2
Doramectin 2
Nitenpyram 2
Fluralaner Chew Tablets 2
Testosterone Propionate;Estradiol Benzoate 2

Reduced conception rate Reaction Insights

105 reports name Reduced conception rate; 4 recorded a death outcome (3.8% of reported events, not a population-level mortality rate). VeDDRA code: 1163.

By species: Cattle (56 reports), Dog (39 reports), Pig (4 reports). By breed: Holstein-Friesian also known as Holstein (24), Retriever - Golden (13), Mixed (Cattle) (8).

Most co-reported drugs: Sometribove (17 reports), Monensin Sodium (16 reports), Spinosad (15 reports), Imidacloprid + Moxidectin (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.