Reaction profile

The FDA adverse-event record for injection site discharge nos

51 FDA adverse-event reports reference injection site discharge nos (VeDDRA 3056). See the species, breeds, and drugs most associated with it below.

51
reports citing this reaction
7.8%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
51
Total Reports
4
Deaths
7.8%
Death Rate

Species Most Affected

Dog 48
Cat 2
Horse 1

Breeds Most Affected

Retriever - Labrador 14
Bulldog - French 6
Pit Bull 4
Retriever - Golden 3
Boxer (German Boxer) 3
Shepherd Dog - Australian 2
Dog (unknown) 2
Schnauzer - Miniature 2
Spaniel - Cocker American 2
Hound (unspecified) 1

Associated Drugs

Tigilanol Tiglate 28
Diphenhydramine 20
Gabapentin 18
Famotidine 17
Prednisone 15
Maropitant Citrate 10
Butorphanol 5
Dexmedetomidine Hydrochloride 5
Butorphanol Tartrate 5
Propofol 5
Trazodone 5
Atipamezole Hydrochloride 4
Buprenorphine 4
Methadone 4
Moxidectin 3
Bedinvetmab 3
Oclacitinib Maleate 3
Lidocaine 3
Isoflurane 2
Dd (Presumably Dexdomitor) 2

Injection site discharge NOS Reaction Insights

51 reports name Injection site discharge NOS; 4 recorded a death outcome (7.8% of reported events, not a population-level mortality rate). VeDDRA code: 3056.

By species: Dog (48 reports), Cat (2 reports), Horse (1 reports). By breed: Retriever - Labrador (14), Bulldog - French (6), Pit Bull (4).

Most co-reported drugs: Tigilanol Tiglate (28 reports), Diphenhydramine (20 reports), Gabapentin (18 reports), Famotidine (17 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.