Reaction profile

The FDA adverse-event record for haemorrhagic gastroenteritis

451 FDA adverse-event reports reference haemorrhagic gastroenteritis (VeDDRA 316). See the species, breeds, and drugs most associated with it below.

451
reports citing this reaction
18.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
451
Total Reports
84
Deaths
18.6%
Death Rate

Species Most Affected

Dog 437
Cattle 7
Cat 5
Pig 1
Horse 1

Breeds Most Affected

Retriever - Labrador 40
Crossbred Canine/dog 28
Terrier - Yorkshire 28
Chihuahua 25
Dog (unknown) 19
Retriever - Golden 16
Beagle 12
Maltese 11
Shepherd Dog - Australian 11
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 10

Associated Drugs

Milbemycin Oxime + Spinosad 52
Carprofen 50
Maropitant Citrate 32
Moxidectin 30
Milbemycin Oxime + Praziquantel 28
Grapiprant 28
Ivermectin + Pyrantel As Pamoate Salt 25
Oclacitinib Maleate 22
Meloxicam 21
Fluralaner Chew Tablets 21
Gabapentin 20
Afoxolaner 19
Metronidazole 16
Prednisone 14
Trilostane 14
Famotidine 14
Sarolaner 14
Pyrantel Pamoate;Sarolaner 14
Bedinvetmab 13
Spinosad 12

Haemorrhagic gastroenteritis Reaction Insights

451 reports name Haemorrhagic gastroenteritis; 84 recorded a death outcome (18.6% of reported events, not a population-level mortality rate). VeDDRA code: 316.

By species: Dog (437 reports), Cattle (7 reports), Cat (5 reports). By breed: Retriever - Labrador (40), Crossbred Canine/dog (28), Terrier - Yorkshire (28).

Most co-reported drugs: Milbemycin Oxime + Spinosad (52 reports), Carprofen (50 reports), Maropitant Citrate (32 reports), Moxidectin (30 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.