Reaction profile

The FDA adverse-event record for increased borborygmus

533 FDA adverse-event reports reference increased borborygmus (VeDDRA 2091). See the species, breeds, and drugs most associated with it below.

533
reports citing this reaction
3.0%
death-coded share
Dog
most-affected species
Ivermectin + Pyrantel As Pamoate Salt
most-associated drug
Verify with FDA CVM →
533
Total Reports
16
Deaths
3.0%
Death Rate

Species Most Affected

Dog 514
Cat 13
Horse 5
Human 1

Breeds Most Affected

Retriever - Labrador 35
Crossbred Canine/dog 35
Chihuahua 33
Boxer (German Boxer) 23
Terrier - Yorkshire 22
Beagle 15
Retriever - Golden 15
Shih Tzu 14
Shepherd Dog - German 13
Dog (unknown) 13

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 51
Milbemycin Oxime + Spinosad 50
Afoxolaner 48
Fluralaner Chew Tablets 28
Grapiprant 22
Lufenuron + Milbemycin Oxime 20
Pyrantel Pamoate;Sarolaner 20
Milbemycin Oxime + Praziquantel 18
Milbemycin Oxime 17
Milbemycin Oxime, Lufenuron 17
Carprofen 16
Oclacitinib Maleate 16
Sarolaner 16
Moxidectin 15
Gabapentin 13
Bedinvetmab 13
Maropitant Citrate 12
Trilostane 12
Imidacloprid + Moxidectin 12
Spinosad 11

Increased borborygmus Reaction Insights

533 reports name Increased borborygmus; 16 recorded a death outcome (3.0% of reported events, not a population-level mortality rate). VeDDRA code: 2091.

By species: Dog (514 reports), Cat (13 reports), Horse (5 reports). By breed: Retriever - Labrador (35), Crossbred Canine/dog (35), Chihuahua (33).

Most co-reported drugs: Ivermectin + Pyrantel As Pamoate Salt (51 reports), Milbemycin Oxime + Spinosad (50 reports), Afoxolaner (48 reports), Fluralaner Chew Tablets (28 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.