Reaction profile

The FDA adverse-event record for fly biting behaviour

550 FDA reports name fly biting behaviour, a high-volume reaction in the CVM extract (VeDDRA 2469). Plate stamps and neighbourhood peers follow.

#606 of 2,481
by report volume (all reactions)
550
reports citing this reaction
5.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Fly biting behaviour has 550 reports now versus 531 in that prior snapshot: 19 more (3.6%).

Report change
+19
Death-coded reports
+2
Death-coded share
+0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Fly biting behaviour changes

FDA AER · VeDDRA plate

Code 2469 VOL-MID

VOL-MID · DEATH-PAR · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 550 reports
  • DEATH-PAR 5.8%
  • UPPER-Q #606/2481
  • PHOTO-FINISH Increased borborygmus
  • SPECIES-DOG Dog · 536
  • DRUG-LEAD Afoxolaner · 106
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Increased borborygmus (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Fly biting behaviour

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Gastric ulcer · near551Fly biting behaviour · this …550Increased borborygmus · near550Pallor · near550Unexplained death · near550Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Fly biting behaviour

Fly biting behaviour: low death-coded share in the FDA AER plate

Signature read: 550 reports place Fly biting behaviour in the upper third of FDA AER volume (#606 of 2,481). Report volume is upper-third scale: 550 named reports in the openFDA extract. Death-coded share is lower-third: 32 of 550 reports (5.8% of named reports). Nearest volume peer: Increased borborygmus (±0 reports). Lead species Dog (536). Lead co-reported drug Afoxolaner (106).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Afoxolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 536
Cat 9
Horse 5

Breeds Most Affected

Retriever - Labrador 52
Crossbred Canine/dog 51
Retriever - Golden 29
Chihuahua 26
Shepherd Dog - German 24
Mountain Dog - Bernese 21
Spaniel - King Charles Cavalier 16
Terrier - Yorkshire 14
Shepherd Dog - Australian 13
Schnauzer - Miniature 12

Associated Drugs

Afoxolaner 106
Pyrantel Pamoate;Sarolaner 101
Sarolaner 77
Fluralaner 13.64% 12-Week Chew 52
Fluralaner Chew Tablets 35
Milbemycin Oxime + Spinosad 32
Ivermectin + Pyrantel As Pamoate Salt 30
Oclacitinib Maleate 20
Moxidectin 15
Lotilaner 15
Ivermectin 12
Carprofen 12
Anti-Il31 Mab Mcs Lot #1283563 12
Milbemycin Oxime + Praziquantel 11
Fluralaner 5.46% 1-Month Chew 9
Milbemycin Oxime 8
Selamectin 8
Bedinvetmab 8
Gabapentin 7
Spinosad 6

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Fly biting behaviour, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (550 here).

Similar death-coded share

Nearest other reactions by death-coded share (5.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Fly biting behaviour (#606 of 2,481 by report volume); death-coded 5.8%. PlainBreed reaction plate · report volume stamp 550 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →