Reaction profile

The FDA adverse-event record for ear infection nos

2,062 FDA adverse-event reports reference ear infection nos (VeDDRA 1435). See the species, breeds, and drugs most associated with it below.

2,062
reports citing this reaction
4.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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2,062
Total Reports
82
Deaths
4.0%
Death Rate

Species Most Affected

Dog 1,894
Cat 159
Cattle 5
Human 1
Rabbit 1
Horse 1
Ferret 1

Breeds Most Affected

Retriever - Labrador 328
Retriever - Golden 127
Domestic Shorthair 97
Shepherd Dog - German 93
Crossbred Canine/dog 82
Shih Tzu 73
Dog (unknown) 59
Boxer (German Boxer) 55
Beagle 49
Spaniel - Cocker American 46

Associated Drugs

Milbemycin Oxime + Spinosad 679
Oclacitinib Maleate 219
Milbemycin Oxime + Praziquantel 217
Afoxolaner 107
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 91
Trilostane 89
Spinosad 86
Bedinvetmab 85
Pyrantel Pamoate;Sarolaner 80
Ivermectin + Pyrantel As Pamoate Salt 73
Prednisone 67
Maropitant Citrate 61
Anti-Il31 Mab Mcs Lot #1283563 61
Carprofen 56
Lotilaner 56
Gabapentin 55
Fluralaner 13.64% 12-Week Chew 54
Betamethasone + Florfenicol + Terbinafine 53
Fluralaner Chew Tablets 48
Cyclosporine 46

Ear infection NOS Reaction Insights

2,062 reports name Ear infection NOS; 82 recorded a death outcome (4.0% of reported events, not a population-level mortality rate). VeDDRA code: 1435.

By species: Dog (1,894 reports), Cat (159 reports), Cattle (5 reports). By breed: Retriever - Labrador (328), Retriever - Golden (127), Domestic Shorthair (97).

Most co-reported drugs: Milbemycin Oxime + Spinosad (679 reports), Oclacitinib Maleate (219 reports), Milbemycin Oxime + Praziquantel (217 reports), Afoxolaner (107 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.