Reaction profile

The FDA adverse-event record for impaired vision

936 FDA adverse-event reports reference impaired vision (VeDDRA 407). See the species, breeds, and drugs most associated with it below.

936
reports citing this reaction
15.4%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
936
Total Reports
144
Deaths
15.4%
Death Rate

Species Most Affected

Dog 700
Cat 198
Human 21
Horse 5
Cattle 5
Donkey 3
Goat 2
Other Birds 1
Other 1

Breeds Most Affected

Domestic Shorthair 108
Retriever - Labrador 67
Crossbred Canine/dog 49
Terrier - Yorkshire 35
Chihuahua 29
Shih Tzu 26
Dog (unknown) 22
Unknown 22
Shepherd Dog - German 21
Shepherd Dog - Australian 20

Associated Drugs

Milbemycin Oxime + Spinosad 90
Bedinvetmab 62
Enrofloxacin 60
Ivermectin 60
Spinosad 57
Afoxolaner 57
Ivermectin + Pyrantel As Pamoate Salt 36
Trilostane 34
Carprofen 31
Maropitant Citrate 31
Imidacloprid + Moxidectin 29
Fluralaner Chew Tablets 28
Cefovecin 25
Recombinant Human Insulin 25
Selamectin 24
Gabapentin 24
Prednisone 23
Sarolaner 21
Pyrantel Pamoate;Sarolaner 21
Frunevetmab 20

Impaired vision Reaction Insights

936 reports name Impaired vision; 144 recorded a death outcome (15.4% of reported events, not a population-level mortality rate). VeDDRA code: 407.

By species: Dog (700 reports), Cat (198 reports), Human (21 reports). By breed: Domestic Shorthair (108), Retriever - Labrador (67), Crossbred Canine/dog (49).

Most co-reported drugs: Milbemycin Oxime + Spinosad (90 reports), Bedinvetmab (62 reports), Enrofloxacin (60 reports), Ivermectin (60 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.