Reaction profile

The FDA adverse-event record for rubbing

969 FDA reports name rubbing, a high-volume reaction in the CVM extract (VeDDRA 2496). Plate stamps and neighbourhood peers follow.

#402 of 2,481
by report volume (all reactions)
969
reports citing this reaction
1.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Rubbing has 969 reports now versus 943 in that prior snapshot: 26 more (2.8%).

Report change
+26
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Rubbing changes

FDA AER · VeDDRA plate

Code 2496 VOL-MID

VOL-MID · DEATH-LOW · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 969 reports
  • DEATH-LOW 1.4%
  • UPPER-Q #402/2481
  • PHOTO-FINISH Apnoea
  • SPECIES-DOG Dog · 645
  • DRUG-LEAD Moxidectin · 173
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Apnoea (±2 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Rubbing

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abnormal movement NOS · near978Rubbing · this reaction969Apnoea · near967Necropsy performed · near967Impaired vision · near963Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Rubbing

Rubbing: low death-coded share in the FDA AER plate

Signature read: Rubbing's 1.4% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is upper-third scale: 969 named reports in the openFDA extract. Death-coded share is lower-third: 14 of 969 reports (1.4% of named reports). Nearest volume peer: Apnoea (±2 reports). Lead species Dog (645). Lead co-reported drug Moxidectin (173).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Moxidectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 645
Cattle 177
Cat 116
Horse 23
Donkey 6
Goat 2

Breeds Most Affected

Domestic Shorthair 70
Aberdeen Angus 57
Crossbred Canine/dog 51
Retriever - Labrador 45
Cattle (unknown) 44
Terrier - Yorkshire 44
Cattle (other) 31
Shih Tzu 29
Chihuahua 29
Retriever - Golden 27

Associated Drugs

Moxidectin 173
Ivermectin 0.5% Pour-On Topical Solution 66
Imidacloprid + Moxidectin 58
Portech App Gun 65 Ml Ivomec/Eprinex 57
Selamectin 47
Afoxolaner 43
Fluralaner Chew Tablets 39
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 39
Oclacitinib Maleate 33
Buprenorphine 30
Fluralaner 13.64% 12-Week Chew 28
Maropitant Citrate 27
Milbemycin Oxime + Praziquantel 26
Nitenpyram 24
Fluralaner Spot-On Solution 24
Carprofen 23
Eprinomectin 5 Mg/Ml Pour-On Solution 22
Anti-Il31 Mab Mcs Lot #1283563 21
Lotilaner 20
Prednisone 19

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Rubbing, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (969 here).

Similar death-coded share

Nearest other reactions by death-coded share (1.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Rubbing (#402 of 2,481 by report volume); death-coded 1.4%. PlainBreed reaction plate · death-coded share stamp 1.4% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →