Reaction profile

The FDA adverse-event record for rubbing

913 FDA adverse-event reports reference rubbing (VeDDRA 2496). See the species, breeds, and drugs most associated with it below.

913
reports citing this reaction
1.3%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
913
Total Reports
12
Deaths
1.3%
Death Rate

Species Most Affected

Dog 601
Cattle 175
Cat 109
Horse 20
Donkey 6
Goat 2

Breeds Most Affected

Domestic Shorthair 68
Aberdeen Angus 57
Crossbred Canine/dog 46
Cattle (unknown) 43
Retriever - Labrador 42
Terrier - Yorkshire 40
Cattle (other) 31
Shih Tzu 28
Chihuahua 28
Retriever - Golden 22

Associated Drugs

Moxidectin 160
Ivermectin 0.5% Pour-On Topical Solution 66
Imidacloprid + Moxidectin 57
Portech App Gun 65 Ml Ivomec/Eprinex 57
Selamectin 45
Afoxolaner 43
Fluralaner Chew Tablets 39
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 37
Oclacitinib Maleate 32
Buprenorphine 29
Maropitant Citrate 27
Fluralaner 13.64% 12-Week Chew 27
Milbemycin Oxime + Praziquantel 25
Fluralaner Spot-On Solution 24
Eprinomectin 5 Mg/Ml Pour-On Solution 22
Carprofen 22
Nitenpyram 20
Lotilaner 19
Gabapentin 19
Doramectin 18

Rubbing Reaction Insights

913 reports name Rubbing; 12 recorded a death outcome (1.3% of reported events, not a population-level mortality rate). VeDDRA code: 2496.

By species: Dog (601 reports), Cattle (175 reports), Cat (109 reports). By breed: Domestic Shorthair (68), Aberdeen Angus (57), Crossbred Canine/dog (46).

Most co-reported drugs: Moxidectin (160 reports), Ivermectin 0.5% Pour-On Topical Solution (66 reports), Imidacloprid + Moxidectin (57 reports), Portech App Gun 65 Ml Ivomec/Eprinex (57 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.