Reaction profile

The FDA adverse-event record for defecation related to convulsion

153 FDA adverse-event reports reference defecation related to convulsion (VeDDRA 2771). See the species, breeds, and drugs most associated with it below.

153
reports citing this reaction
10.5%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
153
Total Reports
16
Deaths
10.5%
Death Rate

Species Most Affected

Dog 145
Cat 8

Breeds Most Affected

Crossbred Canine/dog 13
Retriever - Labrador 11
Retriever - Golden 10
Shih Tzu 7
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 6
Chihuahua 6
Pug 6
Shepherd Dog - German 5
Boxer (German Boxer) 4
Terrier - Yorkshire 4

Associated Drugs

Afoxolaner 40
Fluralaner 13.64% 12-Week Chew 31
Ivermectin + Pyrantel As Pamoate Salt 23
Gabapentin 8
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 7
Fluralaner 5.46% 1-Month Chew 6
Pimobendan 5
Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 5
Doxycycline 5
Milbemycin Oxime + Spinosad 4
Meloxicam 4
Milbemycin Oxime + Praziquantel 4
Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet 4
Phenobarbital 3
Famotidine 3
Moxidectin 3
Sarolaner 3
Diazepam 3
Isoflurane 3
Fipronil + S-Methoprene 3

Defecation related to convulsion Reaction Insights

153 reports name Defecation related to convulsion; 16 recorded a death outcome (10.5% of reported events, not a population-level mortality rate). VeDDRA code: 2771.

By species: Dog (145 reports), Cat (8 reports). By breed: Crossbred Canine/dog (13), Retriever - Labrador (11), Retriever - Golden (10).

Most co-reported drugs: Afoxolaner (40 reports), Fluralaner 13.64% 12-Week Chew (31 reports), Ivermectin + Pyrantel As Pamoate Salt (23 reports), Gabapentin (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.