Reaction profile

The FDA adverse-event record for circling - neurological disorder (see also 'behavioural disorders')

1,965 FDA reports name circling - neurological disorder (see also 'behavioural disorders'), a high-volume reaction in the CVM extract (VeDDRA 652). Plate stamps and neighbourhood peers follow.

#237 of 2,481
by report volume (all reactions)
1,965
reports citing this reaction
25.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Circling - neurological disorder (see also 'Behavioural disorders') has 1,459 reports now versus 1,459 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Circling - neurological disorder (see also 'Behavioural disorders') changes

FDA AER · VeDDRA plate

Code 652 VOL-MID

VOL-MID · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,965 reports
  • DEATH-HOT 25.3%
  • TOP-DECILE #237/2481
  • PHOTO-FINISH Elevated symmetrical…
  • SPECIES-DOG Dog · 1,190
  • DRUG-LEAD Milbemycin Oxime… · 146
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Elevated symmetrical dimethylarginine (SDMA) (±1 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Circling - neurological disorder

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Hypokalaemia · near1980Circling - neurologic… · thi…1965Elevated symmetrical… · near1964Blood in urine · near1952Icterus · near1950Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Circling - neurological disorder (see also 'Behavioural disorders')

Circling - neurological disorder (see also 'Behavioural disorders'): high death-coded share in the FDA AER plate

Signature read: 497 death-coded reports is a heavy tail count for Circling - neurological disorder (see also 'Behavioural disorders') in the CVM extract. Report volume is upper-third scale: 1,965 named reports in the openFDA extract. Death-coded share is upper-third: 497 of 1,965 reports (25.3% of named reports). Nearest volume peer: Elevated symmetrical dimethylarginine (SDMA) (±1 reports). Lead species Dog (1,190). Lead co-reported drug Milbemycin Oxime + Spinosad (146).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,190
Cat 219
Horse 24
Cattle 12
Rabbit 5
Goat 1
Other Deer 1
Other 1
Sheep 1
Donkey 1

Breeds Most Affected

Domestic Shorthair 114
Retriever - Labrador 94
Crossbred Canine/dog 86
Chihuahua 64
Shih Tzu 55
Terrier - Yorkshire 54
Maltese 53
Retriever - Golden 39
Boxer (German Boxer) 33
Terrier (unspecified) 28

Associated Drugs

Milbemycin Oxime + Spinosad 146
Afoxolaner 110
Carprofen 93
Spinosad 84
Selamectin 68
Maropitant Citrate 68
Fluralaner Chew Tablets 63
Ivermectin + Pyrantel As Pamoate Salt 59
Pyrantel Pamoate;Sarolaner 59
Sarolaner 56
Cefovecin 50
Trilostane 45
Moxidectin 44
Fluralaner 13.64% 12-Week Chew 38
Meloxicam 36
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 36
Imidacloprid + Moxidectin 30
Oclacitinib Maleate 30
Nitenpyram 27
Prednisone 25

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Circling - neurological disorder (see also 'Behavioural disorders'), both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,965 here).

Similar death-coded share

Nearest other reactions by death-coded share (25.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Circling - neurological disorder (see also 'Behavioural disorders') (#237 of 2,481 by report volume); death-coded 25.3%. PlainBreed reaction plate · death-coded report count stamp 497 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →