Reaction profile

The FDA adverse-event record for hyperkalaemia

3,045 FDA adverse-event reports reference hyperkalaemia (VeDDRA 1944). See the species, breeds, and drugs most associated with it below.

3,045
reports citing this reaction
20.3%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
3,045
Total Reports
618
Deaths
20.3%
Death Rate

Species Most Affected

Dog 2,680
Cat 299
Horse 54
Tiger 2
Jaguar 2
Human 2
Cattle 2
Pig 1
Lion 1
Wolf 1

Breeds Most Affected

Retriever - Labrador 188
Domestic Shorthair 163
Chihuahua 162
Crossbred Canine/dog 147
Shih Tzu 138
Terrier - Yorkshire 125
Maltese 117
Terrier - Boston 106
Beagle 89
Spaniel (unspecified) 71

Associated Drugs

Trilostane 2,292
Carprofen 153
Meloxicam 123
Maropitant Citrate 118
Gabapentin 101
Milbemycin Oxime + Spinosad 97
Oclacitinib Maleate 78
Afoxolaner 72
Bedinvetmab 71
Insulin 69
Prednisone 67
Deracoxib 61
Enalapril 56
Grapiprant 52
Pimobendan 50
Cefovecin 45
Moxidectin 44
Firocoxib 44
Levothyroxine 43
Spinosad 42

Hyperkalaemia Reaction Insights

3,045 reports name Hyperkalaemia; 618 recorded a death outcome (20.3% of reported events, not a population-level mortality rate). VeDDRA code: 1944.

By species: Dog (2,680 reports), Cat (299 reports), Horse (54 reports). By breed: Retriever - Labrador (188), Domestic Shorthair (163), Chihuahua (162).

Most co-reported drugs: Trilostane (2,292 reports), Carprofen (153 reports), Meloxicam (123 reports), Maropitant Citrate (118 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.