Reaction profile

The FDA adverse-event record for not himself/herself

2,811 FDA adverse-event reports reference not himself/herself (VeDDRA 2753). See the species, breeds, and drugs most associated with it below.

2,811
reports citing this reaction
13.1%
death-coded share
Dog
most-affected species
Pyrantel Pamoate;Sarolaner
most-associated drug
Verify with FDA CVM →
2,811
Total Reports
367
Deaths
13.1%
Death Rate

Species Most Affected

Dog 2,160
Cat 630
Horse 17
Cattle 4

Breeds Most Affected

Domestic Shorthair 354
Retriever - Labrador 221
Crossbred Canine/dog 155
Retriever - Golden 123
Terrier - Yorkshire 100
Chihuahua 98
Shepherd Dog - German 85
Terrier - Bull - American Pit 70
Shih Tzu 67
Dog (unknown) 62

Associated Drugs

Pyrantel Pamoate;Sarolaner 517
Bedinvetmab 406
Fluralaner 13.64% 12-Week Chew 210
Maropitant Citrate 180
Gabapentin 174
Moxidectin 134
Carprofen 129
Frunevetmab 121
Oclacitinib Maleate 115
Selamectin;Sarolaner 104
Sarolaner 95
Trilostane 88
Lotilaner 83
Buprenorphine 72
Milbemycin Oxime + Praziquantel 72
Prednisone 66
Fluralaner/Moxidectin Spot-On 65
Fluralaner Spot-On Solution 65
Nitenpyram 65
Afoxolaner 63

Not himself/herself Reaction Insights

2,811 reports name Not himself/herself; 367 recorded a death outcome (13.1% of reported events, not a population-level mortality rate). VeDDRA code: 2753.

By species: Dog (2,160 reports), Cat (630 reports), Horse (17 reports). By breed: Domestic Shorthair (354), Retriever - Labrador (221), Crossbred Canine/dog (155).

Most co-reported drugs: Pyrantel Pamoate;Sarolaner (517 reports), Bedinvetmab (406 reports), Fluralaner 13.64% 12-Week Chew (210 reports), Maropitant Citrate (180 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.