Reaction profile

The FDA adverse-event record for liver nodules

89 FDA adverse-event reports reference liver nodules (VeDDRA 2904). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1449 of 2,481
by report volume (all reactions)
89
reports citing this reaction
42.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Liver nodules has 89 reports now versus 85 in that prior snapshot: 4 more (4.7%).

Report change
+4
Death-coded reports
+0
Death-coded share
−2.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Liver nodules changes

FDA AER · VeDDRA plate

Code 2904 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 89 reports
  • DEATH-HOT 42.7%
  • MID-PACK #1449/2481
  • PHOTO-FINISH Cervical pain
  • SPECIES-DOG Dog · 75
  • DRUG-LEAD Bedinvetmab · 27
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Cervical pain (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Liver nodules

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Cervical pain · near89Hepato-biliary disord… · near89Injection site self t… · near89Liver nodules · this reaction89Spleen hypertrophy · near89Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Liver nodules

Liver nodules: high death-coded share in the FDA AER plate

Signature read: Liver nodules's 42.7% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 38 of 89 reports (42.7% of named reports). Nearest volume peer: Cervical pain (±0 reports). Lead species Dog (75). Lead co-reported drug Bedinvetmab (27).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 75
Cat 14

Breeds Most Affected

Retriever - Labrador 14
Crossbred Canine/dog 10
Domestic Shorthair 5
Retriever - Golden 5
Collie - Border 5
Terrier (unspecified) 4
Terrier - Bull - American Pit 3
Siberian Husky 3
Boxer (German Boxer) 2
Siamese 2

Associated Drugs

Bedinvetmab 27
Carprofen 19
Maropitant Citrate 18
Gabapentin 15
Capromorelin 11
Ursodiol 11
Trilostane 10
Ondansetron 7
Metronidazole 7
Leptospirosis Vaccine 7
Enrofloxacin 7
Buprenorphine 6
Doxycycline 6
Ampicillin/Sulbactam 6
Intravenous Fluids 5
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 5
Pyrantel Pamoate;Sarolaner 5
Grapiprant 5
Insulin Injectable Vial 5
Fluralaner 13.64% 12-Week Chew 5

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Liver nodules, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (89 here).

Similar death-coded share

Nearest other reactions by death-coded share (42.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Liver nodules (#1449 of 2,481 by report volume); death-coded 42.7%. PlainBreed reaction plate · death-coded share stamp 42.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →