Reaction profile

The FDA adverse-event record for frequent urination

1,445 FDA reports name frequent urination, a high-volume reaction in the CVM extract (VeDDRA 733). Plate stamps and neighbourhood peers follow.

#293 of 2,481
by report volume (all reactions)
1,445
reports citing this reaction
8.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Frequent urination has 1,445 reports now versus 1,412 in that prior snapshot: 33 more (2.3%).

Report change
+33
Death-coded reports
+5
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Frequent urination changes

FDA AER · VeDDRA plate

Code 733 VOL-MID

VOL-MID · DEATH-PAR · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,445 reports
  • DEATH-PAR 8.8%
  • UPPER-Q #293/2481
  • PHOTO-FINISH Immune mediated haemo…
  • SPECIES-DOG Dog · 1,286
  • DRUG-LEAD Bedinvetmab · 220
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Immune mediated haemolytic anaemia (±10 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Frequent urination

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Head bobbing · near1461Tiredness · near1456Immune mediated haemo… · near1455Frequent urination · this re…1445Sedation · near1426Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Frequent urination

What the FDA AER plate says about Frequent urination

Signature read: 1,445 reports place Frequent urination in the upper third of FDA AER volume (#293 of 2,481). Report volume is upper-third scale: 1,445 named reports in the openFDA extract. 127 of 1,445 reports were death-coded (8.8% of named reports, not a population mortality rate). Nearest volume peer: Immune mediated haemolytic anaemia (±10 reports). Lead species Dog (1,286). Lead co-reported drug Bedinvetmab (220).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bedinvetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,286
Cat 139
Horse 13
Cattle 5
Human 1
Goat 1

Breeds Most Affected

Retriever - Labrador 146
Crossbred Canine/dog 82
Retriever - Golden 77
Domestic Shorthair 74
Shepherd Dog - German 65
Dog (unknown) 40
Chihuahua 36
Boxer (German Boxer) 36
Beagle 34
Shepherd Dog - Australian 33

Associated Drugs

Bedinvetmab 220
Milbemycin Oxime + Spinosad 121
Oclacitinib Maleate 92
Pyrantel Pamoate;Sarolaner 86
Afoxolaner 81
Trilostane 77
Gabapentin 72
Carprofen 69
Fluralaner Chew Tablets 56
Lotilaner 56
Spinosad 52
Maropitant Citrate 50
Prednisone 49
Ivermectin + Pyrantel As Pamoate Salt 39
Grapiprant 39
Milbemycin Oxime + Praziquantel 37
Moxidectin 35
Fluralaner 13.64% 12-Week Chew 35
Sarolaner 31
Enrofloxacin 29

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Frequent urination, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,445 here).

Similar death-coded share

Nearest other reactions by death-coded share (8.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Frequent urination (#293 of 2,481 by report volume); death-coded 8.8%. PlainBreed reaction plate · report volume stamp 1,445 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →