Reaction profile

The FDA adverse-event record for frequent urination

1,356 FDA adverse-event reports reference frequent urination (VeDDRA 733). See the species, breeds, and drugs most associated with it below.

1,356
reports citing this reaction
8.6%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
1,356
Total Reports
117
Deaths
8.6%
Death Rate

Species Most Affected

Dog 1,211
Cat 127
Horse 11
Cattle 5
Human 1
Goat 1

Breeds Most Affected

Retriever - Labrador 143
Crossbred Canine/dog 75
Retriever - Golden 74
Domestic Shorthair 66
Shepherd Dog - German 63
Dog (unknown) 38
Chihuahua 34
Boxer (German Boxer) 34
Terrier - Yorkshire 32
Shepherd Dog - Australian 31

Associated Drugs

Bedinvetmab 197
Milbemycin Oxime + Spinosad 121
Oclacitinib Maleate 82
Pyrantel Pamoate;Sarolaner 81
Afoxolaner 74
Trilostane 70
Carprofen 64
Gabapentin 64
Fluralaner Chew Tablets 56
Lotilaner 55
Spinosad 52
Prednisone 45
Maropitant Citrate 44
Grapiprant 38
Ivermectin + Pyrantel As Pamoate Salt 36
Milbemycin Oxime + Praziquantel 36
Moxidectin 34
Fluralaner 13.64% 12-Week Chew 34
Sarolaner 30
Enrofloxacin 28

Frequent urination Reaction Insights

1,356 reports name Frequent urination; 117 recorded a death outcome (8.6% of reported events, not a population-level mortality rate). VeDDRA code: 733.

By species: Dog (1,211 reports), Cat (127 reports), Horse (11 reports). By breed: Retriever - Labrador (143), Crossbred Canine/dog (75), Retriever - Golden (74).

Most co-reported drugs: Bedinvetmab (197 reports), Milbemycin Oxime + Spinosad (121 reports), Oclacitinib Maleate (82 reports), Pyrantel Pamoate;Sarolaner (81 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.