Reaction profile

The FDA adverse-event record for gingival disorder

187 FDA adverse-event reports reference gingival disorder (VeDDRA 1885). See the species, breeds, and drugs most associated with it below.

187
reports citing this reaction
13.9%
death-coded share
Dog
most-affected species
Cyclosporine A
most-associated drug
Verify with FDA CVM →
187
Total Reports
26
Deaths
13.9%
Death Rate

Species Most Affected

Dog 154
Cat 16
Horse 14
Human 2
Cattle 1

Breeds Most Affected

Retriever - Labrador 22
Shih Tzu 11
Chihuahua 10
Dog (unknown) 9
Crossbred Canine/dog 8
Domestic Shorthair 8
Shepherd Dog - German 7
Boxer (German Boxer) 6
Retriever - Golden 6
Pit Bull 5

Associated Drugs

Cyclosporine A 21
Cyclosporine 19
Carprofen 17
Milbemycin Oxime + Spinosad 14
Oclacitinib Maleate 14
Trilostane 11
Ivermectin, Praziquantel 8
Afoxolaner 8
Meloxicam 7
Ivermectin 7
Ketoconazole 7
Doxycycline Hyclate 7
Spinosad 6
Isoflurane 6
Melarsomine Dihydrochloride 5
Doxycycline 5
Prednisone 5
Selamectin 4
Maropitant Citrate 4
Buprenorphine 4

Gingival disorder Reaction Insights

187 reports name Gingival disorder; 26 recorded a death outcome (13.9% of reported events, not a population-level mortality rate). VeDDRA code: 1885.

By species: Dog (154 reports), Cat (16 reports), Horse (14 reports). By breed: Retriever - Labrador (22), Shih Tzu (11), Chihuahua (10).

Most co-reported drugs: Cyclosporine A (21 reports), Cyclosporine (19 reports), Carprofen (17 reports), Milbemycin Oxime + Spinosad (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.