Reaction profile

The FDA adverse-event record for decreased pulse oxygenation

177 FDA adverse-event reports reference decreased pulse oxygenation (VeDDRA 2486). See the species, breeds, and drugs most associated with it below.

177
reports citing this reaction
50.3%
death-coded share
Dog
most-affected species
Isoflurane
most-associated drug
Verify with FDA CVM →
177
Total Reports
89
Deaths
50.3%
Death Rate

Species Most Affected

Dog 146
Cat 26
Human 3
Other Mammals 1
Horse 1

Breeds Most Affected

Domestic Shorthair 14
Chihuahua 10
Retriever - Golden 9
Retriever - Labrador 9
Bulldog - French 8
Shepherd Dog - Australian 7
Dog (unknown) 7
Domestic Longhair 6
Crossbred Canine/dog 6
Dachshund (unspecified) 6

Associated Drugs

Isoflurane 32
Maropitant Citrate 24
Moxidectin 18
Carprofen 17
Propofol 16
Melarsomine Dihydrochloride 15
Dexmedetomidine Hydrochloride 13
Butorphanol 12
Enrofloxacin 11
Butorphanol Tartrate 10
Doxycycline 10
Meloxicam 10
Furosemide 9
Ketamine 9
Buprenorphine 9
Bedinvetmab 9
Oclacitinib Maleate 8
Prednisone 8
Dexamethasone 8
Cefazolin 8

Decreased pulse oxygenation Reaction Insights

177 reports name Decreased pulse oxygenation; 89 recorded a death outcome (50.3% of reported events, not a population-level mortality rate). VeDDRA code: 2486.

By species: Dog (146 reports), Cat (26 reports), Human (3 reports). By breed: Domestic Shorthair (14), Chihuahua (10), Retriever - Golden (9).

Most co-reported drugs: Isoflurane (32 reports), Maropitant Citrate (24 reports), Moxidectin (18 reports), Carprofen (17 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.