Reaction profile

The FDA adverse-event record for enlarged kidney(s)

177 FDA adverse-event reports reference enlarged kidney(s) (VeDDRA 2253). See the species, breeds, and drugs most associated with it below.

177
reports citing this reaction
45.8%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
177
Total Reports
81
Deaths
45.8%
Death Rate

Species Most Affected

Dog 87
Cat 87
Fish 1
Horse 1
Chicken 1

Breeds Most Affected

Domestic Shorthair 51
Retriever - Labrador 12
Domestic Mediumhair 9
Retriever - Golden 7
Cat (unknown) 6
Persian 6
Hound - Basset 5
Crossbred Canine/dog 4
Shepherd Dog - German 4
Bichon Frise 3

Associated Drugs

Maropitant Citrate 39
Cefovecin 21
Meloxicam 15
Robenacoxib 15
Carprofen 14
Buprenorphine 13
Fluralaner Chew Tablets 12
Gabapentin 11
Cefovecin Sodium 9
Oclacitinib Maleate 8
Bedinvetmab 8
Ketamine 7
Bexagliflozin 7
Selamectin 6
Famotidine 6
Afoxolaner 6
Mirtazapine 6
Butorphanol 6
Acepromazine 6
Isoflurane 6

Enlarged kidney(s) Reaction Insights

177 reports name Enlarged kidney(s); 81 recorded a death outcome (45.8% of reported events, not a population-level mortality rate). VeDDRA code: 2253.

By species: Dog (87 reports), Cat (87 reports), Fish (1 reports). By breed: Domestic Shorthair (51), Retriever - Labrador (12), Domestic Mediumhair (9).

Most co-reported drugs: Maropitant Citrate (39 reports), Cefovecin (21 reports), Meloxicam (15 reports), Robenacoxib (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.