Reaction profile

The FDA adverse-event record for enlarged kidney(s)

191 FDA adverse-event reports reference enlarged kidney(s) (VeDDRA 2253). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1064 of 2,481
by report volume (all reactions)
191
reports citing this reaction
43.5%
death-coded share
Cat
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Enlarged kidney(s) has 191 reports now versus 184 in that prior snapshot: 7 more (3.8%).

Report change
+7
Death-coded reports
+0
Death-coded share
−1.7 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Enlarged kidney(s) changes

FDA AER · VeDDRA plate

Code 2253 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-CAT · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 191 reports
  • DEATH-HOT 43.5%
  • MID-PACK #1064/2481
  • PHOTO-FINISH Bloody stool
  • SPECIES-CAT Cat · 95
  • DRUG-LEAD Maropitant Citrate · 43
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Bloody stool (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Enlarged kidney

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Bloody stool · near191Decreased pulse oxyge… · near191Dizziness · near191Enlarged kidney(s) · this re…191Gingival disorder · near191Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Enlarged kidney(s)

Enlarged kidney(s): high death-coded share in the FDA AER plate

Signature read: Enlarged kidney(s)'s 43.5% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 83 of 191 reports (43.5% of named reports). Nearest volume peer: Bloody stool (±0 reports). Lead species Cat (95). Lead co-reported drug Maropitant Citrate (43).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cat 95
Dog 89
Horse 3
Chicken 2
Fish 1
Cattle 1

Breeds Most Affected

Domestic Shorthair 58
Retriever - Labrador 13
Domestic Mediumhair 9
Retriever - Golden 7
Cat (unknown) 6
Persian 6
Hound - Basset 5
Crossbred Canine/dog 4
Shepherd Dog - German 4
Bichon Frise 3

Associated Drugs

Maropitant Citrate 43
Cefovecin 21
Robenacoxib 18
Buprenorphine 16
Meloxicam 15
Carprofen 14
Fluralaner Chew Tablets 12
Gabapentin 11
Cefovecin Sodium 10
Isoflurane 10
Bedinvetmab 9
Oclacitinib Maleate 8
Bexagliflozin 8
Ketamine 7
Midazolam 7
Ampicillin 6
Selamectin 6
Famotidine 6
Afoxolaner 6
Mirtazapine 6

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Enlarged kidney(s), both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (191 here).

Similar death-coded share

Nearest other reactions by death-coded share (43.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Enlarged kidney(s) (#1064 of 2,481 by report volume); death-coded 43.5%. PlainBreed reaction plate · death-coded share stamp 43.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →