Reaction profile

The FDA adverse-event record for pitting oedema

133 FDA adverse-event reports reference pitting oedema (VeDDRA 2887). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1249 of 2,481
by report volume (all reactions)
133
reports citing this reaction
26.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Pitting oedema has 133 reports now versus 123 in that prior snapshot: 10 more (8.1%).

Report change
+10
Death-coded reports
+0
Death-coded share
−2.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Pitting oedema changes

FDA AER · VeDDRA plate

Code 2887 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 133 reports
  • DEATH-HOT 26.3%
  • MID-PACK #1249/2481
  • PHOTO-FINISH Gastric dilation
  • SPECIES-DOG Dog · 121
  • DRUG-LEAD Bedinvetmab · 38
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Gastric dilation (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Pitting oedema

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Gastric dilation · near133Generalised allergic… · near133Pitting oedema · this reacti…133Application site muco… · near132Cyanotic mucous membr… · near132Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Pitting oedema

Pitting oedema: high death-coded share in the FDA AER plate

Signature read: Pitting oedema's 26.3% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 35 of 133 reports (26.3% of named reports). Nearest volume peer: Gastric dilation (±0 reports). Lead species Dog (121). Lead co-reported drug Bedinvetmab (38).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 121
Horse 7
Cat 4
Ferret 1

Breeds Most Affected

Retriever - Labrador 27
Dog (unknown) 8
Boxer (German Boxer) 7
Crossbred Canine/dog 6
Bulldog - French 6
Shepherd Dog - German 5
Weimaraner 4
Pit Bull 4
Beagle 4
Retriever - Golden 3

Associated Drugs

Bedinvetmab 38
Tigilanol Tiglate 36
Gabapentin 29
Carprofen 26
Maropitant Citrate 21
Diphenhydramine 16
Prednisone 15
Famotidine 14
Propofol 10
Oclacitinib Maleate 10
Butorphanol 9
Dexmedetomidine 9
Moxidectin 8
Polysulfated Glycosaminoglycan 6
Buprenorphine 6
Isoflurane 6
Atipamezole 6
Anti-Il31 Mab Mcs Lot #1283563 6
Trazodone 6
Hydromorphone 5

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Pitting oedema, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (26.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Pitting oedema (#1249 of 2,481 by report volume); death-coded 26.3%. PlainBreed reaction plate · death-coded share stamp 26.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →