Reaction profile

The FDA adverse-event record for blepharospasm

484 FDA adverse-event reports reference blepharospasm (VeDDRA 423). See the species, breeds, and drugs most associated with it below.

484
reports citing this reaction
3.9%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
484
Total Reports
19
Deaths
3.9%
Death Rate

Species Most Affected

Dog 367
Cat 108
Cattle 5
Horse 2
Goat 2

Breeds Most Affected

Domestic Shorthair 60
Crossbred Canine/dog 32
Chihuahua 32
Retriever - Labrador 29
Shih Tzu 28
Maltese 20
Domestic (unspecified) 11
Terrier - Jack Russell 11
Retriever - Golden 11
Boxer (German Boxer) 11

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 76
Milbemycin Oxime + Spinosad 75
Imidacloprid + Moxidectin 41
Carprofen 28
Maropitant Citrate 27
Enrofloxacin 25
Prednisone 23
Spinosad 21
Cyclosporine 19
Moxidectin 16
Tobramycin 16
Selamectin 15
Gabapentin 14
Pilocarpine 14
Florfenicol, Terbinafine, Betamethasone Acetate 14
Diphenhydramine 13
Buprenorphine 13
Bedinvetmab 13
Afoxolaner 12
Oclacitinib Maleate 12

Blepharospasm Reaction Insights

484 reports name Blepharospasm; 19 recorded a death outcome (3.9% of reported events, not a population-level mortality rate). VeDDRA code: 423.

By species: Dog (367 reports), Cat (108 reports), Cattle (5 reports). By breed: Domestic Shorthair (60), Crossbred Canine/dog (32), Chihuahua (32).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (76 reports), Milbemycin Oxime + Spinosad (75 reports), Imidacloprid + Moxidectin (41 reports), Carprofen (28 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.