Reaction profile

The FDA adverse-event record for regurgitation

1,057 FDA adverse-event reports reference regurgitation (VeDDRA 1888). See the species, breeds, and drugs most associated with it below.

1,057
reports citing this reaction
16.2%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
1,057
Total Reports
171
Deaths
16.2%
Death Rate

Species Most Affected

Dog 975
Cat 65
Horse 6
Human 3
Parrot 2
Turtle 2
Snake 1
Pig 1
Pigeon 1
Other 1

Breeds Most Affected

Retriever - Labrador 118
Crossbred Canine/dog 64
Dog (unknown) 53
Retriever - Golden 45
Terrier - Yorkshire 34
Pit Bull 31
Domestic Shorthair 30
Boxer (German Boxer) 28
Bulldog - French 26
Rottweiler 25

Associated Drugs

Maropitant Citrate 162
Carprofen 115
Milbemycin Oxime + Spinosad 98
Gabapentin 75
Deracoxib 60
Enrofloxacin 55
Afoxolaner 54
Propofol 51
Tramadol 48
Metoclopramide 47
Ivermectin + Pyrantel As Pamoate Salt 46
Bedinvetmab 43
Butorphanol 42
Famotidine 41
Moxidectin 40
Midazolam 40
Oclacitinib Maleate 40
Isoflurane 39
Meloxicam 38
Fentanyl 36

Regurgitation Reaction Insights

1,057 reports name Regurgitation; 171 recorded a death outcome (16.2% of reported events, not a population-level mortality rate). VeDDRA code: 1888.

By species: Dog (975 reports), Cat (65 reports), Horse (6 reports). By breed: Retriever - Labrador (118), Crossbred Canine/dog (64), Dog (unknown) (53).

Most co-reported drugs: Maropitant Citrate (162 reports), Carprofen (115 reports), Milbemycin Oxime + Spinosad (98 reports), Gabapentin (75 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.